The "Minutemen", a team of costumed crime fighters, was formed in 1939 in response to a rise in costumed gangs and criminals; the "Watchmen" was similarly formed decades later. Their existence has dramatically affected world events: in particular, Doctor Manhattan's superpowers help the United States win the Vietnam War, resulting in President Richard Nixon being reelected. Doctor Manhattan gives the West a strategic advantage over the Soviet Union, which by the 1980s threatens to escalate the Cold War into a nuclear war. During that time, growing anti-vigilante sentiment in the country leads to masked crime-fighters being outlawed. While many of the heroes retire, Doctor Manhattan and the Comedian operate as government-sanctioned agents, and Rorschach continues to operate outside the law.
Michael Sullivan Sr. (Hanks) is an enforcer for Irish mob boss John Rooney (Newman) in Rock Island, Illinois during the Great Depression. Rooney raised the orphan Sullivan and loves him more than his own biological son, the unstable Connor (Craig). Connor snaps and kills disgruntled associate Finn McGovern when meeting him with Sullivan, resulting in Sullivan gunning down McGovern's men. Sullivan's twelve-year-old son Michael Sullivan, Jr had hidden in his father's car and witnesses the event. Despite Sullivan swearing his son to secrecy and Rooney pressuring Connor to apologize for the reckless action, Connor murders Sullivan's wife Annie and younger son Peter, mistaking him for Sullivan, Jr. He then sends Sullivan to an ambush at a speakeasy but Sullivan realizes and escapes to Chicago with his son to seek Al Capone, for work and to discover the location of Connor, who has gone into hiding.
In 1899, men dressed as German soldiers, using a large armored vehicle and wielding machine guns, attacked the Bank of England and stole Leonardo da Vinci’s layouts of Venice’s foundations. Shortly after, led by their leader the “Fantom”, men dressed as British officers, again using highly advanced technology for the time, kidnapped German scientists and destroyed a factory, causing tension between the United Kingdom and Germany, which could lead to an international war. Sanderson Reed (Tom Goodman-Hill) of the British Empire ventures to Kenya, visiting a Gentleman's club to recruit world-renowned hunter and adventurer Allan Quatermain (Sean Connery). Quatermain, retired and mourning the loss of his son after his last adventure, has no interest in serving the British Empire further. After armed men attempt to assassinate Quatermain, he is left with no-other choice but to agree to go with Reed to London and meet with Reed's superior officer to help keep the threat of a war from spilling into Africa.
Matt Murdock is a blind lawyer in New York City's Hell's Kitchen neighborhood, where he runs a firm with best friend Franklin "Foggy" Nelson. As a child, Matt was blinded by a toxic waste spill while walking home from school after discovering that his father, former boxer Jack "The Devil" Murdock, had become an enforcer for a local mobster. The accident enhanced Matt's other senses and gave him sonar to "see" via sonic vibrations. Matt trained himself in martial arts. Blaming himself for Matt's disability, Jack stopped being an enforcer, returned to boxing, and was killed after refusing to turn in a fixed fight for the mobster who had employed him earlier. After his Fathers death, Young Matthew promised to stop all crime that controlled Hell's Kitchen, New York as the vigilante crime-fighter "Daredevil".
Friends Reed Richards (Miles Teller) and Ben Grimm (Jamie Bell) have worked together on a prototype teleporter since childhood, eventually attracting the attention of Professor Franklin Storm (Reg E. Cathey), director of the Baxter Foundation, a government-sponsored research institute for young prodigies. Reed is recruited to join them and aid Storm's children, scientist Sue Storm (Kate Mara) and the somewhat reckless technician Johnny Storm (Michael B. Jordan), into completing a "Quantum Gate" designed by Storm's wayward protégé, Victor von Doom (Toby Kebbell), who begrudgingly agrees to help due to his unrequited feelings for Sue.
At Culver University in Virginia, General Thunderbolt Ross meets with Dr. Bruce Banner, the colleague and boyfriend of his daughter Betty, regarding an experiment that Ross claims is meant to make humans immune to gamma radiation. The experiment — part of a World War II era "super soldier" program that Ross hopes to recreate — fails, and the exposure to gamma radiation causes Banner to transform into the Hulk for brief periods of time, whenever his heart rate rises above 200. The Hulk destroys the lab and injures or kills the people inside. Banner becomes a fugitive from the U.S. military and Ross in particular, who wants to weaponize the Hulk process.
During Christmas 1955, an 11-year-old Hellboy is told a bedtime story by his adoptive father, Trevor Broom, involving an ancient war between man and magical creatures, started by man's greed. After defeat of the magical creatures' forces, the master of the goblin blacksmiths offers to build an indestructible mechanical army for the elven King Balor. Encouraged by his son Prince Nuada, Balor orders the building of this Golden Army. The humans are devastated by the army. Balor is ridden with guilt and forms a truce with the humans: Man will keep his cities and the magical creatures will keep their forests. Nuada does not agree with the truce and leaves in exile. The magical crown controlling the army is broken into three pieces, one going to the humans and the other two kept by the elves.
Over the two years since the death of Deacon Frost, Blade (Wesley Snipes), the Daywalker, a vampire unaffected by sunlight and who chooses to defend humans and fight other vampires, has been trying to find his mentor Whistler (Kris Kristofferson), who survived his suicide attempt in the first crisis. Blade has been sweeping across Russia and eastern Europe, enlisting the aid of a young man, Scud (Norman Reedus), to design him a new line of gadgetry and weaponry. Blade carves his way through a large gang of vampires, sparing one, Rush (Santiago Segura), when he promises to reveal Whistler's location. Blade tells Rush he will be back for him. Blade finds Whistler locked in a tank by a gang of vampires who were keeping him alive to torture. Blade rescues Whistler and brings him back to the lair, ridding the latter's vampirism with a cure developed by Dr. Karen Jenson.
Three years after the previous film, while trying to lead a normal life with girlfriend Sarah Ross (Mary-Louise Parker), Frank Moses (Bruce Willis) is approached by Marvin Boggs (John Malkovich), who claims people are still after them, but Frank dismisses him. After appealing a second time, Marvin drives off, and his car explodes. Although Frank does not believe Marvin is dead, Sarah convinces him to go to Marvin's funeral where he delivers a teary-eyed eulogy. After the funeral, a group of government agents approach Frank and take him to be interrogated at a Yankee White Facility. During the interrogation, Jack Horton (Neal McDonough) appears with an armed SWAT team, kills most of the facility's personnel, and tells Frank that he will torture Sarah until he gets information out of Frank. Frank escapes from the room, evades Horton's assassins, and with the sudden timely help of Marvin, who turns out to be alive, goes on the run with Sarah. Marvin explains that he and Frank are being hunted because they were listed as participants in a Clandestine operation codenamed Nightshade, conducted during the Cold War to smuggle a nuclear weapon into Russia piece by piece. Horton has convinced world agencies that Frank and his crew are terrorists and must be stopped. Victoria (Helen Mirren) calls, telling Frank she has been contracted by MI6 to kill the three of them. Meanwhile, top contract killer Han Cho-Bai (Lee Byung-hun), whom Horton knows is seeking revenge on Frank, is also hired.
A French priest named Moreau warns the monks of a monastery about an impending attack by the devil's forces to obtain a boy named Danny. The monastery falls under attack; Moreau tries to help the boy and his mother Nadya escape, but the distrusting mother shoots at Moreau and flees with her son. Moreau manages to distract the men chasing Danny and Nadya, but nearly dies in the process and loses them. He believes that only the Ghost Rider is capable of protecting the boy. He finds the Rider and seeks his help.
In the late 2020s the world is in turmoil, with the United States fractured as a result of prolonged conflict and a pandemic of the "St. Mary's Virus" ravaging Europe. The United Kingdom is ruled as a fascist police state by the Norsefire Party. Political opponents, immigrants, Muslims, homosexuals and other "undesirables" are imprisoned in concentration camps. On November 4, a Guy Fawkes-masked vigilante identifing himself as "V" (Hugo Weaving) rescues Evey Hammond (Natalie Portman), an employee of the state-run British Television Network (BTN), from members of the "Fingermen" secret police while she is out past curfew. From a rooftop, they watch his demolition of the Old Bailey criminal court building, accompanied by fireworks and the 1812 Overture. Inspector Finch (Stephen Rea), Scotland Yard's Chief of Police, is tasked with investigating V's activities while BTN declares the incident an "emergency demolition". V interrupts the broadcast to claim responsibility and urges the people of Britain to rise up against their government. He asks them to meet him exactly one year later, on November 5, Guy Fawkes Night, outside the Houses of Parliament, which he promises to destroy. During the broadcast, the police attempt to capture V. Evey helps him escape but is knocked unconscious.
A group of vampires look for the hidden resting place of Drake, also known as Dracula—the genetic "father" of their species. They find him in a Syrian ziggurat tomb, although not before, in a moment of blood lust, he kills one of them. The vampires capitalize on Blade's reputation as a serial killer and frame him for the killing of a familiar. During the ensuing manhunt, the FBI locate Blade's latest hideout, and, during the siege, Abraham Whistler dies. With his mentor gone and surrounded by human authorities, Blade allows himself to be captured and arrested.
In 1944, the Nazis build a dimensional portal off the coast of Scotland. With the help of Russian mystic Grigori Rasputin, they intend to free the Ogdru Jahad—monstrous entities imprisoned in deep space—to aid them in defeating the Allies. Rasputin knows this will be an apocalyptic event that he believes will create a paradise. He opens the portal with the aid of his disciples, Ilsa von Haupstein and Obersturmbannführer Karl Ruprecht Kroenen, member of the Thule Society and Adolf Hitler's top assassin. An Allied team is sent to destroy the portal, guided by young Trevor Bruttenholm, who is well-versed in the occult. The German team is killed and the portal is destroyed—in the process absorbing Rasputin—while Haupstein and Kroenen escape. The Allied team discovers that an infant demon with a right hand of stone came through the portal; they dub him "Hellboy" and Bruttenholm adopts him.
Dave Lizewski (Aaron Johnson) is an ordinary teenager who lives in Staten Island, New York. Dave purchases a bodysuit and makes modifications to it. He then embarks on a campaign to become a real-life superhero, armed with a couple of batons. During his first attempt to fight crime, he becomes the victim of a stabbing and a hit and run. This leaves him with multiple fractures and metal plates, all of which cause him to require extensive rehabilitation. In the process of recovery, he gains a capacity to endure pain and enhanced durability. In his absence from school, a rumor spreads that he is gay, as he was found naked by the paramedics after discarding his costume. As a result, his longtime crush, Katie Deauxma (Lyndsy Fonseca), immediately attempts to become his friend.