Half-witted longtime friends Albert (Luis Manzano), Isaac (Billy Crawford), Mozart “Mo” (DJ Durano), Michaelangelo “Mike” (Martin Escudero) and Aristotle “Aris” (Marvin Agustin) were used to living moronic yet pretty normal and hassle-free lives until successful careerwoman Beckie Pamintuan (John Lapus) accused them of killing her father and ruin everything for them. The Moron 5 are more than sure of their innocence but for the life of them, they can't find any single satisfactory argument on how to prove it especially when their opponent would do everything to punish them for whim. Spending three miserable years in prison trying different failed comedic attempts to get out, they finally figured a way to escape. They stalked Beckie and tried to understand why she's fighting so hard to have them imprisoned when it's clear as day that what happened three years ago was a nonsense frame-up. An opportunity came when Beckie's driver got fired for having an affair with her maid and Albert volunteered to apply to replace him. He infiltrated the Pamintuan Residence and together with his four crazily daft friends, they've gathered information about the curious family yet to them, it isn't making any sense at all especially Vecky's unexplained hatred to the five of them. Why is Beckie fighting so hard to have them suffer? The Moron 5 will try harder to know and hopefully understand what's really going on although little did they know that by doing so, everything that they hold dear might be at risk.
Bernadette "Detty" Sabroso is the daughter of the wealthy couple Raphael (Epi Quizon) and Kara Sabroso (Rubi-Rubi), who own a large silk factory. Raphael also has an illegitimate son, Bernard, with his former maid Maria Laurel (Beauty Gonzalez). When Maria and Bernard have nowhere else to go, Raphael takes both of them in. Unaware that they are siblings, Bernard, who is gay, and Detty become close friends, as both share their love for fashion. When Kara discovers Raphael and Maria sleeping with each other, as well as realizing that Raphael is Bernard's father, she confronts them in front of Bernard and Detty, kicks them out and accidentally pushes Maria down the stairs, severely injuring her. With no assistance from the family or the other maids, Bernard swears vengeance against the Sabroso family.
With three years of a happy relationship, Mike (Luis Manzano) decided to end his relationship with his gay lover, Lester (Vice Ganda), After their break-up, Lester soon finds out that Mike is cheating with him for the last year with a bank accountant Gemma (Toni Gonzaga). This leads to Lester having a plan to destroy Mike and Gemma's relationship, by acting like a real man and thinking that Mike will come back to him. He commanded his four gay friends and also his workers on his parlor, Babushka (IC Mendoza), Ricky (Lassie Marquez), Fanny (Ricky Rivero) and Bambi (Ricci Chan) to pretend as a group of hold-uppers to hold-up Gemma after her shift. Lester pretends to be her "knight and shining armor" and saves her from the "hold-uppers" (his friends). After the rackus, Gemma took Lester home to bring her to her parents (Boboy Garovillo and Carla Martinez). After a dinner with the rest of Gemma's family, Lester went home. He stopped by his parlor and shocked at his friend's broken faces (the bruises he left after he saved Gemma from them). After they tried to have their revenge on him, he soon apologized and get together again. Gemma called Mike that same evening, telling him that Mike should meet with Lester in order for him to learn martial arts, which he declines. With his family's suffering for poorness, Mike doesn't know where to get money for his and Gemma's wedding. He proposed to Gemma, which caused Lester to have his plan.
Roanne Sanchez, a young girl with high ideals about romance is assigned to accompany the spoiled son of the president, Eric Rodriguez (Gerald Anderson) as he goes on an immersion trip. Coming from different worlds, the two find much to fight about, but sudden attraction between then soon gets the better of them.
Furniture supplier Ram (Derek Ramsay) is happily married to Charmaine (Cristine Reyes). One day, Ram lands a big client, a new luxury resort. But he needs the help of Kara (Anne Curtis), the daughter of the owner of the resort, to finalize the deal. Kara's help, however, comes with a price, because she fancies Ram to be her lover. Not before long, Kara successfully seduces Ram, even though she knows about his marriage. When Charmaine learns of the affair, she finds ways to fight for her husband's waning attention.
Benjamin "Benjie" Santos VIII (Vice Ganda) comes from a long line of warriors and soldiers. His grandfather, Benjamin Santos VI (Eddie Garcia), expects him to be in the army and to be like his ancestors who fought every battle in the country. He lives with his parents and two sisters named Jesamine (Angelie Urquico) and Anjamin (Abby Bautista). His father, Benjamin Santos VII (Jimmy Santos), gave up being a military soldier to be what he wants to be, a scientist and an inventor. Benjie's grandfather did not agree with his decision, so they were forced to leave his grandfather's house and to never come back. They now live in a cramped house, where they started a new life. His father, as expected, followed what makes him happy. He invented gadgets and unique deadly weapons. Some examples are the Fart-gun, or the Utot-gun in Tagalog, a fan that shoots bullets, and a tiara that can kill thousands of people.
In the academe, Nicolas “Nico” Veneracion Borromeo is a highly esteemed History of Architecture professor who is on his way to becoming the next Vice Dean of the Department. He knows that achieving this would finally make his mother proud of him and forgive him for indirectly causing his father’s death.
After twenty years, local police capture the murderer of the older brother of a young boy. Now a doctor, he must go back to his old town and face the murderers himself. He then discovers that the murderers are Aswangs (folkloric Filipino vampire-like creatures) and they pose a deadly threat not only to him but also for the entire town.
It has been six months since Laida Magtalas and Miggy Montenegro became a couple. Laida was promoted from executive assistant to executive accountant, while Miggy has been doing well as he is being mentored by his older brother Art Montenegro. Laida gets an offer from her aunt to work in Canada where she is being given a good recommendation.
In 1898, a band of Spanish soldiers heroically defended Baler (which was later made the provincial capital of Aurora in 1951) against Filipino revolutionary forces for 337 long and grueling days. This battle, now known as the Siege of Baler, is the setting of a forbidden love between a mestizo soldier (Jericho Rosales) and a native Filipina (Anne Curtis) who lived at the end of the 19th century.
Benedicto "Ben" Caballero is an environmentalist who disapproves of deforestation for villages in mountainous regions in the country. He is more concerned of the environment than that of getting along with his siblings. It is revealed that he was a former lawyer and that he quit because of a matter between right or wrong, and not about winning or losing. He focuses on nature-for him, it's all about saving the planet.
The story revolves around Georgia, a Filipina patis (fish sauce) manufacturer and a mother who is finally reunited with her long-lost Filipino Australian daughter after 20 years of separation.
With the weight of an alcoholic née suicidal sister Brigitte (Sunshine Dizon), a womanizing addict for a brother Bogs (John Lapus), a hypochondriac for a mother Lupe (Gina Pareno), and a socially challenged lovelife Mark (Rudy Hatfield) hanging on her shoulders, Boobita Rose (Rufa Mae Quinto) breaks down by breaking into a song. However, she proves to be a tough cookie to crumble and gamely deals with her tribulations through a roller coaster ride of laugh and tears. Regine Velasquez, Ogie Alcasid, Lani Misalucha, and other big-name stars grace the musical interludes and provide added comic relief.
Corazon (Sharon Cuneta) and Clark (Andrew E.) have an adventure throughout Metro Manila running away from kidnappers led by Brando (Bong Alvarez). They escape the kidnappers after a confrontation with Brando in a Jollibee restaurant while eating on a pick up truck to Clark's house where his cousin Bugoy (Smokey Manaloto) and Neneng (Maybelline dela Cruz) live. However the kidnappers locate them when they follow Bugoy who was riding the pick up truck which they recognized while Bugoy was in a gas station refueling the pick up truck to Clark's house causing Clark and Corazon to escape back to Metro Manila to get help leaving Bugoy and Neneng behind unharmed. When they reach the attorney's (Charito Solis) house with help from Clark's boss Mr. Calderon (Jon Achaval) they defeat the kidnappers and Elias (Andy Poe) who is behind the kidnapping attempt on Corazon is arrested by his wife Marga (Gloria Sevilla) who discovered his treachery and she explains to Corazon that her husband is behind on attempt so he wants the money to belong to her. In the end, they became rich.
Famous singer, Monique (Sharon Cuenta) escapes her home after her mother is in disbelief that her stepfather tried to assault her. She goes into hiding by altering her looks and assumes the name, Digna. She goes living in a shelter for women and works various odd jobs. With her past coming back to haunt her again, Monique's fate is altered with a chance encounter with Carding (Robin Padilla), a small, petty thief who looks after six orphaned children.