In the near future, a mercenary named Toorop (Vin Diesel) accepts a contract from a Russian mobster, Gorsky (Gérard Depardieu), who instructs him to bring a young woman known only as Aurora (Mélanie Thierry) to New York City. In order to reach this goal, Gorsky gives Toorop a variety of weapons as well as a UN passport that has to be injected under the skin of the neck. Toorop, along with the girl and her guardian nun Sister Rebeka (Michelle Yeoh), travels from the Noelite Convent in Mongolia to reach New York via Russia.
A disaster of some type has occurred, of which the audience only knows that uncontaminated water is scarce and livestock have to be burned. Fleeing the city, the Laurent family arrive at their country home, hoping to find refuge and security, only to discover that it is already occupied by strangers.
In 2027, after 18 years of global human infertility, civilization is on the brink of collapse as humanity faces extinction. The United Kingdom, the only stable nation with a functioning government, is deluged by asylum seekers fleeing the chaos and war which have taken hold around the world. In response, Britain has become a militarized police state as British government forces round up and detain immigrants. Theo Faron, a former activist turned cynical bureaucrat, is kidnapped by the Fishes, a militant immigrants' rights group. They are led by Theo's estranged wife, Julian Taylor, from whom he separated after their son's death.
The plot-summaries of the shorts are listed below in the order that they run in the DVD release, which is not the chronological order. Chronologically, the order would be:
The Archangel Michael (Paul Bettany) falls to Earth in Los Angeles and cuts off his wings. He steals a police car after a policeman is killed by another officer who is possessed. He travels towards the Paradise Falls Diner, near the edge of the Mojave Desert. Meanwhile, Kyle (Tyrese Gibson), a single father driving to Los Angeles, stops at the diner. He meets the owner, Bob Hanson (Dennis Quaid); Bob's son, Jeep (Lucas Black); Percy (Charles S. Dutton), the short-order cook; Charlie (Adrianne Palicki), a pregnant waitress; Howard (Jon Tenney) and Sandra (Kate Walsh) Anderson, a married couple; and Audrey (Willa Holland), their rebellious teenage daughter. An old woman (Jeanette Miller) enters the diner and begins taunting the diner's patrons. When Howard confronts her, she rips his throat open, screeches that they are all going to die, and climbs up the ceiling. Kyle shoots her before she can kill Jeep. Percy, Kyle, Sandra, Audrey and Charlie try to get Howard to the hospital but they are forced to turn back after passing through a swarm of flies.
Asuka Langley Shikinami and Mari Illustrious Makinami, pilots of giant Evangelion cyborgs, are sent into in space to retrieve a container in which Evangelion Unit 01 and its pilot Shinji Ikari are sealed. When Asuka grabs the container with her Evangelion unit, it releases attack drones. Unit 01 awakens and destroys the drones, then deactivates and descends back to Earth. Kaworu Nagisa watches and says he has been waiting for Shinji.
During the original outbreak of the Rage Virus, Don, his wife Alice, and four other survivors hide in a barricaded cottage on the outskirts of London. They hear a terrified boy pounding at their door, and let him in. A few minutes later, they discover that the infected have followed the boy to them. The infected attack and kill most of the survivors, while Don, Alice, and the boy are chased upstairs. Don is separated from Alice and when the boy is seen hiding in the closet. Alice rushes to get the boy, while Don tells her to just leave him. Soon the infected break into the room and after Alice pleading with Don to "help us", he decides to leave, abandoning them. Don desperately sprints to a nearby motorboat and narrowly escapes.
The human race has been taken over by small parasitic aliens called "Souls". The Souls travel to distant planets inserting themselves individually into a host body of that planet's dominant species. They are able to access the host's memories, and occupied hosts are identifiable by silver rings that form in the hosts' eyes.
After a violent thunderstorm, David Drayton (Thomas Jane), a graphic artist, and wife Stephanie (Kelly Collins Lintz) check the damage. They find a large tree planted by David's grandfather has fallen on the house and another tree belonging to next-door neighbor Brent Norton (Andre Braugher) has demolished their boat house. David and Stephanie notice a strange mist floating across the surface of the lake towards their property.
The United States is devastated by a mysterious phenomenon which reanimates recently deceased unburied human beings as flesh-eating zombies. Despite the best efforts by the U.S. government and local authorities to control the situation, society is beginning to collapse and the remaining survivors are given to chaos. Some rural communities and the military have been effective in fighting the zombies in open country, but cities are helpless and largely overrun. Confusion reigns at the WGON television studio in Philadelphia by the phenomenon's third week, where staff members Stephen Andrews and Francine Parker are planning to steal the station's traffic helicopter to escape the zombies. Meanwhile, police SWAT officer Roger DiMarco and his team raid an apartment building where the residents are defying the martial law of delivering their dead to National Guardsmen. Some residents fight back with handguns and rifles, and are killed by both the overzealous SWAT team and their own reanimated dead. During the raid, Roger meets Peter Washington, part of another SWAT team, and they partner up together. Roger tells Peter that his friend Stephen intends to take his network's helicopter, and suggests that Peter come with them. The matter is decided when they are informed of a group of zombies sheltered in the basement, which they execute with grim determination.
In 2009, a plague caused by an infected vampire bat has transformed most of the world's population into vampires and due to this event, control of the world no longer belongs to humans. The vampires are incapable of aging or dying, but are unprotected against sunlight or any ultraviolet light. The entire vampire world is active at night, and various technological and architecture advances are made to adjust the populated areas to vampires' night cycle (such as UV protective cars, underground railways and paths across the cities, and UV warnings).
In 1988, following a 400% increase in crime, the United States Government has evacuated Manhattan and turned the island into a giant maximum-security prison in which all inmates serve a life sentence. A 50-foot (15 m) containment wall surrounds the island and routes out of Manhattan have been dismantled or mined. Armed helicopters patrol the rivers and harbor.
In 2199, after five years of attacks by an alien race known as Gamilas, the Earth Defense Force launches a counter-offensive near Mars. The fleet's weapons are no match for the Gamilas, who easily wipe out much of the force. During the battle, EDF captain Mamoru Kodai volunteers to use his damaged ship, the destroyer Yukikaze, as a shield to cover Captain Jyuzo Okita's ship, allowing his escape. Mamoru's ship is destroyed.
On 16 July 1988, an orb of light destroys Tokyo and World War III begins. Thirty-one years later, in the city of Neo-Tokyo, Shotaro Kaneda has his bōsōzoku gang, the Capsules, battle their rival gang, the Clowns. While there, Kaneda's best friend, Tetsuo Shima, crashes his motorcycle into Takashi, an esper with psychic powers, who had fled from a secret government laboratory with help from a covert operative. Colonel Shikishima, assisted by another esper called Maseru, has Takashi escorted back to his original lodgings and Tetsuo is abducted. When Kaneda and his gang are interrogated, he encounters Kei, a member of the revolutionary group, and arranges her release along with the Capsules.