George Banks must accept the reality of what his daughter's ascension from daughter to wife, and now, to mother means when placed into perspective against his own stage of life. As the comfortable family unit starts to unravel in his mind, a rapid progression into mid-life crisis is in his future. His journey to regain his youth acts as a catalyst for a kind of "rebirth" of his attitude on life when he and his wife, Nina, find how their lives are about to change as well after Nina unexpectedly becomes pregnant. George must now contend not only with his new status as a grandfather, but to also begin again as a new parent just as he was preparing for retirement and an empty nest for him and Nina.
In 1955, Frank Wheeler (Leonardo DiCaprio) meets April (Kate Winslet) at a party. He is a longshoreman, hoping to be a cashier; she wants to be an actress. Frank later secures a sales position with Knox Machines, for which his father worked for twenty years, and he and April marry. The Wheelers move to 115 Revolutionary Road in suburban Connecticut when April becomes pregnant.
Like the rest of the Ju-on series, the film takes place over a period of time, and is told in a non-linear order as six overlapping vignettes. The overarching plot involves the haunted house of the deceased Saeki family, whose brutal murders caused by Kayako Saeki’s crush on another man led to the creation of a curse. Anyone who enters the house will be cursed and eventually consumed by the ghosts of the Saekis. The vignettes are presented in the following order: Kyoko (京子), Tomoka (朋香), Megumi (恵), Keisuke (圭介), Chiharu (千春), and Kayako (伽椰子).
In 2027, after 18 years of global human infertility, civilization is on the brink of collapse as humanity faces extinction. The United Kingdom, the only stable nation with a functioning government, is deluged by asylum seekers fleeing the chaos and war which have taken hold around the world. In response, Britain has become a militarized police state as British government forces round up and detain immigrants. Theo Faron, a former activist turned cynical bureaucrat, is kidnapped by the Fishes, a militant immigrants' rights group. They are led by Theo's estranged wife, Julian Taylor, from whom he separated after their son's death.
Set after the events of the first film, Babe (now voiced by Elizabeth Daily) and his master, farmer Arthur Hoggett (James Cromwell), are given a welcome home parade after Babe's success as a "sheepdog". One day, Babe inadvertently causes an accident to befall Arthur, who ends up in the hospital. Esme is unsuccessful tending the farm on her own. A few days later, two men from the bank tell her she and Arthur have not paid their rent on time, and at the end of the month, Esme and Arthur will soon be evicted from their farm. Among the many letters from their fans, Esme locates one saying that if she enters Babe in a sheepdog herding contest, held at a fair far away, she will win a large amount of money. She decides to enter Babe instead, and they leave the farm together.
The Archangel Michael (Paul Bettany) falls to Earth in Los Angeles and cuts off his wings. He steals a police car after a policeman is killed by another officer who is possessed. He travels towards the Paradise Falls Diner, near the edge of the Mojave Desert. Meanwhile, Kyle (Tyrese Gibson), a single father driving to Los Angeles, stops at the diner. He meets the owner, Bob Hanson (Dennis Quaid); Bob's son, Jeep (Lucas Black); Percy (Charles S. Dutton), the short-order cook; Charlie (Adrianne Palicki), a pregnant waitress; Howard (Jon Tenney) and Sandra (Kate Walsh) Anderson, a married couple; and Audrey (Willa Holland), their rebellious teenage daughter. An old woman (Jeanette Miller) enters the diner and begins taunting the diner's patrons. When Howard confronts her, she rips his throat open, screeches that they are all going to die, and climbs up the ceiling. Kyle shoots her before she can kill Jeep. Percy, Kyle, Sandra, Audrey and Charlie try to get Howard to the hospital but they are forced to turn back after passing through a swarm of flies.
Kate Holbrook (Tina Fey) is a successful single businesswoman who has always put her career before her personal life. Now in her late thirties, she finally decides to have a child of her own but her plans are dampened when she discovers she has a minuscule chance of becoming pregnant due to her uterus being T-shaped. Also denied the chance to adopt, Kate hires an immature, obnoxious South Philly woman named Angie Ostrowiski (Amy Poehler) to become a surrogate mother for her.
Lucy, Kit, and Mimi are three friends who live in a small Georgia town. While children, they bury a "wish box" in the ground, and vow to dig it up on the night of their high school graduation, also pledging to stay best friends forever; however, as they grow up, their friendship fades due to their different approaches of high school. Lucy becomes the valedictorian, Kit becomes the most popular girl in school, and Mimi faces teenage pregnancy. On the night of their graduation, they keep their promise and get together to open the "wish box". As they start talking again, they remember their old wishes while burying the box: Mimi wanted to travel to California, Lucy wanted to see her mother again, and Kit wanted to get married. Mimi brings up the topic of going to Los Angeles for a record contract audition. They all leave together: Lucy to visit her mom in Tucson, Arizona, and Kit to visit her fiance in Los Angeles.
Minneapolis car salesman Jerry Lundegaard (William H. Macy) is desperate for money. Shep Proudfoot (Steve Reevis), an ex-convict, gives him a name; he travels to Fargo, North Dakota, where he hires two men (Carl Showalter (Steve Buscemi) and Gaear Grimsrud (Peter Stormare)) to kidnap his wife, Jean (Kristin Rudrüd), and ransom her for $80,000, knowing his wealthy father-in-law and boss, Wade Gustafson (Harve Presnell) will pay. In return, Lundegaard will give Showalter and Grimsrud a new 1987 Oldsmobile Cutlass Ciera, and half of the ransom money.
A decade after the events of the first film, Dr. Arthur Neuman is giving a tour of the hall of Norse mythology in Edge City Museum. When Dr. Neuman reaches the part concerning Loki's mask, a man in black becomes increasingly anxious. Dr. Neuman mentions that Loki created the mask and unleashed it on Earth, and that those who wear the mask would have the powers of Loki. When Dr. Neuman mentions that Odin punished Loki with imprisonment, the stranger becomes very angry and transforms, revealing himself to be Loki. The tourists panic and flee, but Dr. Neuman stays to argue with the angry god. Loki takes the mask, but realizes it is a fake. In anger, he removes Dr. Neuman's still talking face from his body and puts it on the mask stand, before getting rid of the guards and storming out of the museum in a whirlwind of rage.
In the Victorian period, two young cousins, Richard and Emmeline Lestrange, and a galley cook, Paddy Button (Leo McKern), survive a shipwreck in the South Pacific and reach a lush tropical island. Paddy cares for the small children and forbids them by "law" from going to the other side of the island, as he found evidence of remains of bloody human sacrifices. He also warns them against eating a scarlet berry which is apparently deadly.
Following the events of Are We There Yet?, Nick Persons (Ice Cube) has married Suzanne (Nia Long) and moved her, Kevin (Philip Daniel Bolden), and Lindsey (Aleisha Allen) into his apartment, also purchasing a 2007 Cadillac Escalade (after the destruction of his Lincoln Navigator SUV). He has also sold his sports memorabilia store to his best friend, Marty (played by Jay Mohr in the first film). While getting ready for an interview with Magic Johnson, Suzanne tells Nick that she is pregnant and they later find out that there will be twins.
Vincent, a real estate agent and father-to-be is invited for dinner by his sister Elisabeth and his brother-in-law Pierre. When Vincent reveals he intends to have his son being baptised as "Adolphe" his hosts object to that. The situation eventually gets out of hand.
Shortly after the events of the previous film, Tiffany (Jennifer Tilly), a former girlfriend and accomplice of serial killer Charles Lee Ray (voice of Brad Dourif), acquires the remains of Chucky from a police evidence locker after bribing and then murdering a police officer with access to the locker. Assuming that Ray's soul still inhabits the doll, Tiffany takes it back to her place. She crudely stitches Chucky back together and reenacts the voodoo ritual which instilled Ray inside the doll ten years ago.