Two best friends, Mindy (Eden Sher) and Jodi (Victoria Justice), plan to unite the outcasts of the school and start a social revolution to get their revenge from the high school's alpha female Whitney (Claudia Lee).
The story follows Clay Riddell, a New England artist. He is a witness to an ugly phenomenon: a mysterious signal broadcast over the global cell phone network turns the majority of his fellow humans into mindless vicious animals. Now he and a few survivors must find and stop 'the pulse' and the person controlling it and reunite with his young son before it's too late.
Freddie Steinmark just wants to play football. After constantly being let down by big colleges he finally catches the eye of one coach. Steinmark heads to Austin where he gives his everything for the game he loves.
In the Land of Oz, the Emerald City's co-leaders the Scarecrow, Tin Woodman, and the Cowardly Lion discover that an evil Jester has stolen the broomstick of the late Wicked Witch of the West and taken control over the Flying Monkeys. With Oz's future at stake, the Scarecrow decides to use his invention called the Rainbow Mover to summon Dorothy Gale to save the kingdom again. But flying monkeys invade the castle and force the trio out the window.
Forty-year-old Christine Lucas wakes up in bed with a man she does not know, in an unfamiliar house. The man explains that he is her husband, Ben, and that she suffered brain damage from a car accident ten years earlier. Christine wakes up every morning with no memory of her life from her early twenties onwards.
Oren Little (Douglas), a realtor by trade, develops self-absorption, turning his back on his neighbors and shunning the notion of kindness to others, after his wife dies; part of his self-absorption is having no patience for children, not even his own now-adult son, from whom he has been estranged. He has a next-door neighbor, Leah (Keaton), whose own husband has likewise died, never having had any children of her own, which leads her to throw her soul and her tears into reviving a singing career that had stagnated.
Ernie Fitzpatrick is a daredevil kid who lives in Terra Dino with his best friend Max Santiago and his trouble-making sister Julia, who likes to bust him. Ernie and Julia live with their mother Sue, who has been chosen as the mother of the year, but she is overprotective of them and often makes them leave notes. Ernie is told to go to the store after school to keep an eye on it, but he disobeys orders and goes with Max to the Terra Dino Museum to sneak into a forbidden part of the area still under construction to see the bones of the ferocious Sarcosuchus. But Julia enters as well and uses a quarter from Ernie to set off the alarm. Julia is able to escape but Ernie and Max get caught by the guards, and Sue grounds Ernie for three weeks. When Ernie finds out Julia did it, he gets sick and tired of how he never gets his own way, but he decides to get his revenge by sneaking out again, but Julia discovers this and follows.