An elderly Homer (Perry Long) sits down in his home and begins writing a lost installment of the Odyssey, the tale of the Isle of the Mists, a story he felt was too terrible to tell before.
A fisherman named Will is fishing with his crew in a large thunderstorm. While trying to pull the fishing net in, a wave hits the ship and one crew member, Joey, is suddenly spit in the face by something. When Will looks back, he sees an invisible creature attack Joey. The crew looks for him but he has already been killed. Meanwhile, a mysterious creature attaches itself to the bottom of the boat.
The film depicts the protest in 1999, as thousands of activists arrive in Seattle, Washington in masses to protest the WTO Ministerial Conference of 1999. The World Trade Organization is considered by protesters to contribute to widening the socioeconomic gap between the rich and the poor while it claims to be fixing it and decreasing world hunger, disease and death.
The plot focuses on six women known as thralls, half-vampires who lack the ability to fly or turn their victims. The thralls are joined by Ashley (Baruc), the sister of one of the thralls, and together they attempt to escape from the control of Mr. Jones (Lamas), a centuries-old vampire with a henchman named Rennie. Leslie opens a dance club in Iowa, while waiting the arrival of her sister Ashley, who grew up in an abusive household. Her father dies of a heart attack, causing Ashley to live with her sister.
The film begins with a high school senior, Josh, who is stunned to see that he unknowningly won an MTV contest to see Carmen Electra, and it was actually his sister, Jen, who won the contest and invites everyone they know in their school. Josh and his classmates arrive on an isolated island (which is later revealed to be located in the Bermuda Triangle) where they have an enormous party, but Josh, who has been dumped by his girlfriend, is not really into the fun. Despite having his best friends Andy and Stack with him, he is angry that Jen, who wanted her brother to have an awesome time, scammed him.