À la fin des années 1970, quand il est accusé par une interview dans L'Express d'être responsable de la tristement célèbre rafle du Vélodrome d'Hiver, le passé rattrape René Bousquet, ancien secrétaire général de la police du régime de Vichy reconverti dans la finance. Pendant quinze ans, il tente de se défendre d'avoir commis un crime contre l'humanité, avec l'aide de ses proches et surtout de ses relations bien placées.
In the near future, a mercenary named Toorop (Vin Diesel) accepts a contract from a Russian mobster, Gorsky (Gérard Depardieu), who instructs him to bring a young woman known only as Aurora (Mélanie Thierry) to New York City. In order to reach this goal, Gorsky gives Toorop a variety of weapons as well as a UN passport that has to be injected under the skin of the neck. Toorop, along with the girl and her guardian nun Sister Rebeka (Michelle Yeoh), travels from the Noelite Convent in Mongolia to reach New York via Russia.
Johnny Mad Dog follows a group of LURD child soldiers fighting in 2003, during the latter part of the Second Liberian Civil War. The actors are mostly aged 10 to 15. All were unknowns when cast; some were themselves child soldiers. The film follows their march towards the capital Monrovia, and follows them in a gritty realistic manner as they move through a series of towns and villages, where they terrify and often execute the populace.