The story may not be linear and exhibits several instances of temporal disruption. A dark-haired woman (Harring) escapes her own murder, surviving a car accident on Mulholland Drive. Injured and in shock, she descends into Los Angeles and sneaks into an apartment which an older, red-headed woman has just vacated. An aspiring actress named Betty Elms (Watts) arrives at the same apartment and finds the dark-haired woman confused, not knowing her own name. The dark-haired woman assumes the name "Rita" after seeing a poster for the film Gilda (1946), starring Rita Hayworth. To help Rita remember her identity, Betty looks in Rita's purse, where she finds a large amount of money and an unusual blue key.
Emmanuelle (Sylvia Kristel) flies to Bangkok to meet her husband Jean (Daniel Sarky), a diplomat, who asks her if she had any other lovers while she was in Paris; she replies that she has not. After taking a nude swim, Emmanuelle is approached by a pretty young girl named Marie-Ange (Christine Boisson), who asks to meet Emmanuelle at her house.
Dr. Bill Capa (Willis), a New York City psychologist, falls into a deep depression after an unstable patient commits suicide in front of him by jumping from his office window. The sight of the bloody body of his patient clad in a bright green dress causes Capa to suffer from psychosomatic color blindness, taking away his ability to see the color red.
Adèle is an introverted 15-year-old high-school student whose classmates gossip constantly about boys. While crossing the street one day, she passes by a woman with short blue hair and is instantly attracted. She dates a boy at her school for a short while and they have sex, but she is ultimately dissatisfied and breaks off their relationship. After having vivid fantasies about the woman she saw on the street and having one of her female friends behave flirtatiously towards her, she becomes troubled about her sexual identity. One friend, the openly gay Valentin, seems to understand her confusion and takes her to a gay dance bar. After some time, Adèle leaves and walks into a lesbian bar, where she experiences assertive advances from some of the women. The blue haired woman is also there and intervenes, claiming Adèle is her cousin to those pursuing Adèle. The woman is Emma, a graduating art student. They become friends and begin to spend more time with each other. Adèle's friends suspect her of being a lesbian and ostracise her at school. Despite the backlash, she becomes very close to Emma. Their bond increases and before long, the two share a kiss at a picnic. They later have sex and begin a passionate relationship. Emma's artsy family is very welcoming to the couple, but Adèle tells her conservative, working-class parents that Emma is just a tutor for philosophy class.
Jill Banford and Ellen March struggle to support themselves by raising chickens on an isolated farm in rural Canada. Dependent Jill tends to household chores and finances while the self-sufficient Ellen deals with heavier work, such as chopping wood, repairing fences, and stalking the fox that keeps raiding their coops, although she is hesitant about killing it. Jill seems content with their secluded existence, but the frustrated Ellen is less enchanted by the solitude.
As he is about to die, Porter's life flashes before him in the form of a musical production staged by the archangel Gabriel in the Indiana theater where the composer first performed on stage.
Justin, a ten-year-old boy living in a small town in the Rhône-Alpes region, is awaken in the middle of the night. His mother, Mireille is crying and his widower grandfather, Victor, tells the boy that his father, Ivan, is dead. The next day, Alex, Justin’s uncle and Ivan’s younger brother, arrives for the funeral accompanied by a young woman, Juliette. Justin notice the tension between the adults. He takes his father's gun and hides it. The story flashes backward and forward to explain what led up to Ivan’s death.
Professor Alfred Kinsey is being interviewed about his sexual history. Interspersed with the interview, are flashbacks from his childhood and young-adulthood. The young child years show his father, a lay minister, denouncing modern inventions as leading to sexual sin, then in early adolescence, humiliating him in a store by denouncing its keeper for showing him cigarettes, while his adolescence shows his experiences as a Boy Scout and a late teenage scene shows Kinsey disappointing his father by his chosen vocational intentions. It then shows adult Kinsey teaching at Indiana University as a professor of biology lecturing on gall wasps. Kinsey falls in love with a student in his class, whom he calls Mac, and marries her. Consummation of their marriage is difficult at first, because of a medical problem Mac has that is fixed easily with minor surgery, after which it is shown that she has an equally intense sexual appetite as her husband. Meanwhile, at the University, Professor Kinsey, who is affectionately called "Prok" by his graduate students, meets with students after hours to offer individual sexual advice. Later, in a fictional scene where his mother has just died and Alfred Jr. is back at his parents home with grieving friends and relatives, ex. his sister being too fat and thus unattractive to get a husband and his brother as a possible early boomerang generation man who moved back home after losing his business, Kinsey shocks his father by telling his "big secret": that he's doing a sex survey and want his father to contribute his own sexual history to it.
Due to an administrative error two male college students, the shy and intellectual Eddy (Josh Charles) and the All-American jock Stuart (Stephen Baldwin), end up with a female roommate. The university thought that Alex (Lara Flynn Boyle) was a man (based on her name) and thus the three students are forced to live with each other until the university can move Alex to a female residence hall.
À l'aube de l'âge moderne, Colette raconte l'histoire d'une femme à qui sa voix a longtemps été refusée en faisant des efforts extraordinaires pour la récupérer. Gabrielle Sidonie Colette, une jeune femme d'un village de campagne, épouse un Parisien charismatique et dominant, son aîné de quatorze ans, connu sous le seul nom de «Willy».
In a voice-over, Chloe discusses her business as a call girl. Catherine is a gynecologist and her husband David is a college professor. Catherine suspects David of having an affair after she sees a cell-phone picture of him with a female student.
One week before her vaginoplasty, Sabrina 'Bree' Osbourne (Felicity Huffman) receives a phone call from Toby Wilkins (Kevin Zegers), a 17-year-old jailed in New York City. He asks for Stanley Schupak (Bree's birth name), claiming to be her son.
On a snowy evening, the middle-aged bachelor Seligman (Stellan Skarsgård) finds the self-diagnosed nymphomaniac Joe (Charlotte Gainsbourg) beaten up and lying in the alleyway behind his apartment. He takes her back to his home and, over tea, listens intently as Joe recounts the eventful story of her libidinous life. Seligman, a highly-educated but cloistered man, connects and analyzes Joe's stories with what he has read about.
Clay Easton (Andrew McCarthy) is a straitlaced college freshman on the east coast, who returns home to Los Angeles, California, for Christmas to find things very different from the way he left them. His high school girlfriend, Blair (Jami Gertz), has become addicted to drugs and has been having sex with his high school best friend, Julian Wells (Robert Downey, Jr.). Julian, whose life has gone downhill after his startup record company falls apart, has become a drug addict. He's also been cut off by his family for stealing to support his habit and reduced to homelessness. Julian is also being hassled by his dealer, an old classmate named Rip (James Spader), for a debt of $50,000 that he owes to him.
Holden McNeil (Ben Affleck) and Banky Edwards (Jason Lee) are comic book artists and lifelong friends. Holden is the friendly, more mild-mannered half of the duo; Banky, meanwhile, is the loud and fiery half. Everything is going well for them until they meet Alyssa Jones (Joey Lauren Adams) at a comic book convention in New York where they are promoting their comic Bluntman and Chronic. Holden is attracted to Alyssa, but soon learns that she is attracted to women. The two begin hanging out, and a deep friendship develops. Eventually, Holden is no longer able to contain his feelings, and confesses his love to Alyssa. She is initially angry with him, but that night, the two begin a romantic relationship.