The film combines clips from Tarkovsky's films with footage of Tarkovsky on the set of his last film The Sacrifice and on his deathbed, during the final stage of his battle with cancer. The film mostly relies on images, with only sparse commentary, and concentrates mainly on giving insight into Tarkovsky's work and philosophy and on exploring the intersections between his private life and his work. The film starts with a scene from Tarkovsky first film Ivan's Childhood and ends with a parallel scene from his last film The Sacrifice. It shows the reunion of Tarkovsky with his son Andrei Jr., who had been allowed to leave the Soviet Union only after Tarkovsky was diagnosed with terminal lung cancer. Apart from Andrei Tarkovsky himself the film shows, among others, his second wife Larisa Tarkovskaya, his son Andrei Jr., the editor of the film The Sacrifice Michal Leszczylowski, the French actress Valérie Mairesse, the Swedish cinematographer Sven Nykvist and the Russian actress Margarita Terekhova.
À Rome en juillet 1966, Pier Paolo Pasolini évoque ses parti pris cinématographiques, notamment au travers de ses films Accattone, Des oiseaux, petits et gros et de L'Évangile selon saint Matthieu.