A jaded pilot named Noah Dugan (Gould) is unemployed and owes a large amount of money due to his gambling. He goes to an old friend, Stoney (Vincent Gardenia), who owns an airfield. He is offered a job flying a cargo of animals to a remote South Pacific island aboard a B-29 bomber, a large plane well past its prime (having born the brunt of U.S. combat against Japan decades earlier during World War II). Bernadette Lafleur (Bujold) is the prim missionary who accompanies him. Bernadette has raised the animals at an orphanage and is close to two of the orphans, Bobby and Julie (Schroder and Tammy Lauren).
In Honolulu, a DC-4 airliner prepares to take off for San Francisco with 17 passengers and a crew of 5. Former captain Dan Roman (John Wayne), the flight's veteran first officer known for his habit of whistling, is haunted by a crash that killed his wife and son and left him with a permanent limp. The captain, Sullivan (Robert Stack), suffers from a secret fear of responsibility after logging thousands of hours looking after the lives of passengers and crew. Young second officer Hobie Wheeler (William Campbell) and veteran navigator Lenny Wilby (Wally Brown) are contrasts in age and experience. Stewardess Spalding (Doe Avedon) attends her passengers, each with varying personal problems, including jaded former actress May Holst (Claire Trevor), unhappily married heiress Lydia Rice (Laraine Day), aging beauty queen Sally McKee (Jan Sterling) and cheerful vacationer Ed Joseph (Phil Harris). Spalding befriends the terminally ill Frank Briscoe (Paul Fix) after being charmed by his pocket watch. A last-minute arrival, Humphrey Agnew (Sidney Blackmer), causes the crew concern with his strange behavior.
When Air Force One is shot down by terrorists leaving the President of the United States William Allan Moore (Samuel L. Jackson) stranded in the wilderness of Finland, there is only one person around who can save him: a 13-year-old boy called Oskari (Onni Tommila). In the forest on a hunting mission to prove his maturity to his kinsfolk, Oskari had been planning to track down a deer, but instead discovers the most powerful man on the planet in an escape pod. With the terrorists closing in to capture their own "Big Game" prize while Pentagon officials watch on satellite broadcast—including the Vice President (Victor Garber), the CIA director (Felicity Huffman), and former CIA field operative Herbert (Jim Broadbent), brought in as a consultant—the unlikely duo must team up to escape their hunters.
Dieter Dengler, a German-born U.S. Navy pilot in squadron VA-145, is shot down in his A-1 Skyraider over Laos in February 1966, while on a combat mission. He survives the crash only to be pursued, and ultimately captured, by the Pathet Lao. Dengler is given the chance for leniency by the Province Governor if he signs a document condemning America, but he refuses. He is tortured and taken to a prison camp. There he meets fellow American military soldiers and pilots, such as Gene DeBruin and Duane W. Martin, along with Y.C., Procet, and Phisit, some of whom have been captive for years. Dengler begins planning an escape, much to the disbelief of his fellow combatants, who have been downtrodden through physical and psychological torture by the camp guards.
While taking a business trip, architect Max Klein (Jeff Bridges) survives a crash of a flight headed from San Francisco to Houston. As the plane descends, Max inexplicably becomes at peace when he accepts he is going to die. The revelation inspires him to comfort many of the fearful passengers, even moving to sit next to Byron Hummel (Daniel Cerny), a young boy flying alone. The psychological trauma of the experience transforms his personality and he enters an altered state of consciousness, rethinking his life and becoming preoccupied with the eternal meanings and the existential questions of life and death itself. Max's reaction to this awakening itself questions the reality of what is real and unreal and what his mind perceives as real through his interaction with others and the chance of living again in everyday life.
During a routine flight to Minneapolis, a passenger (Susan Dey) aboard Global Airways Flight 502, a Boeing 707, discovers a bomb threat written on the mirror of one of the first-class bathrooms. A second threat is soon found left on a napkin in a galley. Captain Hank O'Hara (Charlton Heston) takes the cryptic threats seriously and follows the instructions -- "Bomb on plane divert to Anchorage Alaska. No Joke, No Tricks. Death"—by changing course for Alaska. To avoid an explosive decompression if a bomb goes off, he flies at lower altitude, increasing fuel consumption.
In February 1942, just two months after the Pearl Harbor attack, the United States Army Air Forces plan to retaliate by bombing Tokyo and four other Japanese cities—taking advantage of the fact that US aircraft carriers can approach near enough to the Japanese mainland to make such an attack feasible.
U.S. Navy Lieutenant Harry Brubaker (William Holden) is a Naval Reserve officer and Naval Aviator who was called back to active duty from his civilian profession as an attorney to fly fighter-bombers in the Korean War. Returning from a mission with battle damage, he is forced to ditch into the sea and is rescued by a Sikorsky H-5 helicopter manned by Chief Petty Officer (NAP) Mike Forney (Mickey Rooney) and Airman (NAC) Nestor Gamidge (Earl Holliman).
During the last days of the Vietnam War, USAF Lieutenant Colonel Iceal E. "Gene" Hambleton (Gene Hackman) call sign BAT-21 Bravo, is flying on board a EB-66C electronic warfare aircraft, engaged in electronic countermeasures preparatory to a major bombing strike. Without warning, a number of SA-2 Guideline surface to air missiles are launched from South Vietnam, targeting their aircraft. A massive SAM explosion tears off the tail and Hambleton, in the navigator's position, ejects as the sole survivor of the six-man crew.
Jack Powell and David Armstrong are rivals in the same small American town, both vying for the attentions of pretty Sylvia Lewis. Jack fails to realize that "the girl next door", Mary Preston, is desperately in love with him. The two young men both enlist to become combat pilots in the Air Service. When they leave for training camp, Jack mistakenly believes Sylvia prefers him. She actually prefers David and lets him know about her feelings, but is too kindhearted to turn down Jack's affection.
The film is a story of two soldiers, one American and the other Japanese, marooned on an uninhabited Pacific island, who, in order to survive, must accept their differences and work together, despite their two countries being at war.
In Hawaii, during World War II, U.S. Navy pilot Alec Brooke (Van Johnson) commands a flying boat, named the "High Barbaree". During a bombing mission against a Japanese submarine, his PBY Catalina is shot down with all but one of his crew killed, but still able to stay afloat, adrift far from Allied territory. While the crippled aircraft is slowly floating, the two survivors hear the voice of "Tokyo Rose" (Audrey Totter) invoking memories of their past. Alec shares a series of recollections with fellow survivor, Lt. Joe Moore (Cameron Mitchell). His memories concern his boyhood sweetheart, Nancy Fraser (June Allyson), now a Navy nurse serving on a ship in the Pacific theater, commanded by his uncle, Capt. Thad Vail (Thomas Mitchell).
In London during the Second World War, Lieutenant David Halloran (Harrison Ford), an American, B-25 bomber pilot, with the Eighth Air Force based in England, and Margaret Sellinger (Lesley-Anne Down) an English nurse, meet on Hanover Street in a chance encounter during the Blitz.
Frank Towns (James Stewart) is the pilot of a twin-engine Fairchild C-82 Packet cargo plane flying from Jaghbub to Benghazi in Libya. Lew Moran (Richard Attenborough) is the navigator while the passengers are Capt. Harris (Peter Finch) and Sgt. Watson (Ronald Fraser) of the British Army; Dr. Renaud (Christian Marquand), a physician; Heinrich Dorfmann (Hardy Krüger), a German aeronautical engineer; Mr. Standish (Dan Duryea), an oil company accountant; and several oil workers that include Trucker Cobb (Ernest Borgnine), a mentally-disturbed foreman; Ratbags Crow (Ian Bannen), a mean-spirited, sardonic Scot; Carlos (Alex Montoya) and his pet monkey; and Gabriel (Gabriele Tinti). A sudden sandstorm shuts down the engines, forcing Towns to crash-land in the desert. As the aircraft careens to a stop, several oil drums and oil drilling gear break loose and severely injure Gabriel's leg. Two other workers are killed.
In 1906, a young Baron Manfred von Richthofen (Tomáš Koutník) is out hunting deer, with his younger brother and younger cousin, Lothar and Wolfram, when they hear an aeroplane overhead. Enchanted, he follows it on horseback, waving his arms.