The film opens with a slight introduction from the main hero of the film, Underdog who introduces the audience to himself, his arch-nemesis Simon Barsinister, and Barsinister's henchman Cad. The film then enters into Capital City Town Hall, where a beagle on the police bomb squad sets off a false alarm after smelling a large ham (in some boxes near where the mayor was giving a speech). After being shunned by his fellow police canines, the beagle leaves in shame and is abducted off the street by Cad, who takes him to Simon's lab. Simon is bitter against the mayor, who has turned down his proposal for a type of genetic experimenting for the city, and plans to prove him wrong by testing his new serum on the beagle. However, Underdog escapes and runs amok in the lab, causing a fire and accidentally becoming exposed to a variety of DNA concoctions and chemicals that Simon developed, which modifies his DNA and gives him the strength to break through the metal door to the lab. After witnessing his work's "success" Simon is stunned when a burning monitor falls onto him, and Cad rushes to his aid.
Seven-year-old Johnny is excited about what he believes to be a vacation at his grandmother's Georgia plantation with his parents, John Sr. and Sally. When they arrive at the plantation, he discovers that his parents will be living apart for a while, and he is to live in the country with his mother and grandmother while his father returns to Atlanta to continue his controversial editorship in the city's newspaper. Johnny, distraught because his father has never left him or his mother before, leaves that night under cover of darkness and sets off for Atlanta with only a bindle. As Johnny sneaks away from the plantation, he is attracted by the voice of Uncle Remus telling tales "in his old-timey way" of a character named Br'er Rabbit. Curious, Johnny hides behind a nearby tree to spy on the group of people sitting around the fire. By this time, word has gotten out that Johnny is gone and some plantation residents, who are sent out to find him, ask if Uncle Remus has seen the boy. Uncle Remus replies that he's with him. Shortly afterwards, he catches up with Johnny, who sits crying on a nearby log. He befriends the young boy and offers him some food for the journey, taking him back to his cabin.
The film begins with Ham III, grandson of the first chimpanzee in space, being a cannonball at his circus and later being criticized by his grandfather's friend Houston. Meanwhile, an unmanned NASA space probe called the Infinity is dragged into an intergalactic wormhole, and crash-lands on an Earth-like planet on the other side of the galaxy. Zartog, an evil-minded inhabitant, accidentally discovers how to take manual control of the on-board machinery and uses it to enslave the population.
Dans un futur dystopique, dans la ville japonaise de Megasaki, un virus de la grippe se propage dans toute la population canine grandissante. Le maire autoritaire, Kobayashi (un homme issu d'une longue lignée d'amateurs de chats et haïsseurs de chiens) avec son bras droit le major Domo, signe un décret bannissant tous les chiens à l'Île poubelle (« l'île des déchets » où sont stockés les détritus de la ville), bien que le scientifique Watanabe fasse savoir qu'il est sur le point de trouver un remède. Le premier chien à être banni est Spots, qui appartenait à Atari Kobayashi, le neveu orphelin et pupille du maire.
Eeyore, Rabbit, Tigger, and Pooh are working on a plan to get honey from a beehive. Piglet wants to help, but his friends tell him he is too small. When the plan goes awry, Piglet saves the day by trapping the bees in a decoy hive. But no one notices what Piglet had done. Feeling ignored and unappreciated, Piglet sadly wanders away.
Set in Cambodia during the 1920s during French colonial rule, two tigers; one male and one female, meet and mate. Months later, the tiger couple have given birth to two tiger cubs, who would one day get separated after the ancient temple where they live is disturbed by Aidan McRory (Guy Pearce), who intends to steal and sell the ancient statues at an auction in London.
Norman "Sonny" Steele is a former championship rodeo rider who has sold out to a business conglomerate and is now reduced to making public appearances to sell a brand of breakfast cereal. Prior to making a Las Vegas promotional appearance to ride the $12 million champion thoroughbred race horse who responds to the name of Rising Star, Sonny discovers to his horror that the horse has been drugged and is injured.
Julius Caesar lands in Britain, where a small village still holds out bravely against the Roman legions. But the situation becomes critical and the villagers have not got long to live; that's when Jolitorax, one of the villagers seeks volunteers to go seek help from his second-cousin Asterix the Gaul and bring back a barrel of "magic potion" from the Breton village of the indomitable heroes.
Famed novelist Paul Sheldon (James Caan) is the author of a successful series of Regency romance novels featuring a character named Misery Chastain. Wanting to focus on more serious stories, he writes a manuscript for the final Misery novel. While traveling from Silver Creek, Colorado to his home in New York City, he is caught in a blizzard and his car goes off the road, rendering him unconscious. Paul is rescued by a nurse named Annie Wilkes (Kathy Bates), who brings him to her remote home. When Paul regains consciousness he finds himself bedridden, with both his legs broken as well as a dislocated shoulder. Annie claims she is his "number one fan" and talks a lot about him and his novels. As a reward for saving him, Paul gives Annie his new manuscript which she saved from the wreckage. While feeding him, she is angered and spills soup on him but regains control and apologizes. She buys a copy of Paul's most recently published book, Misery's Child, giving glowing praise to Paul as she progresses through the book. However, when Annie discovers that Misery dies at the end of the book she flies into a rage, almost smashing a table on Paul's head. She reveals that she lied about calling his agent and the authorities; nobody knows where he is. Annie leaves and Paul tries to escape from his room, but she has locked the door.
Physical therapist Dian Fossey (Sigourney Weaver) is inspired by the anthropologist Louis Leakey (Iain Cuthbertson) to devote her life to the study of primates. To this end, she writes ceaselessly to him for a job cataloguing and studying the rare mountain gorillas of Africa. With some effort, she manages to convince Leakey of her conviction and devotion to the cause at hand after personally approaching him following a lecture in Louisville, Kentucky, on his part in 1966. Thereafter, Fossey embarks into the Congo, where Leakey and his foundation equip her with the necessary equipment and housing to achieve personal contact with the gorillas, and introduce her to a local animal tracker, Sembagare (John Omirah Miluwi), to assist her in her endeavors. Settling deep in the jungle, Fossey and Sembagare manage to locate a troop of gorillas, but they are ultimately displaced by the events of the Congo Crisis after being forcibly evicted from their research site by Congolese soldiers, who accuse Fossey of being a foreign spy and agitator.
In 1969, Denver housewife and mother Penny Chenery (Diane Lane) agrees to take over her ailing father, Christopher Chenery's Meadow Stables in Doswell, Virginia, despite her lack of horse-racing knowledge. With the help of veteran trainer Lucien Laurin (Malkovich), Chenery navigates the male-dominated business, ultimately fostering the first Triple Crown winner in 25 years and one of the greatest racehorses of all time.
Sarah Nolan, an attractive 40-year-old divorced preschool teacher, is urged by her family to date more. Although they show her photos of men they want to set her up with, Sarah does not seem interested in pursuing any relationships. Jake Anderson, another recent divorcee, finds himself in a similar position; his lawyer, Charlie, wants to set him up with a woman named Sherry. However, Jake would rather focus on creating his handcrafted boats.
While investigating rumors of a mystical "healing earth" whose powers are said to flow forth from the sacred Gudjara Mountain, geologists Philip and Betsy Ames (Michael Shannon and Nancy Paul) are killed in a cave-in, leaving their young daughter Janet an orphan.
Tom Brand est homme d’affaires, très pressé et ne pensant qu'à sa carrière. Il s'est même éloigné de sa femme Lara et de sa fille Rebecca. Pour l'anniversaire de sa fille, il décide de lui faire cadeau d'un chat, acquis auprès d'un étrange personnage. Après un violent accident, il tombe dans le coma et son esprit est à présent dans la tête de l'animal. Alors qu'il est confronté à ses erreurs passées et à une vie de quadrupède, il va essayer de se racheter auprès des personnes de son entourage.
The Creed family – Louis, Rachel, and their children Ellie and Gage – move from Chicago to Ludlow, Maine, where they befriend elderly neighbor Jud Crandall, who takes them to an isolated pet cemetery hidden behind the Creeds' new home.