Jane Coslaw (Follows), the narrator of the film, is the oldest sister in a dysfunctional family of four. Her narration starts in the Spring of 1976 and centers on her strained relationship with her younger, paraplegic brother Marty (Haim) and their parents Nan and Bob. Their rocky relationship changes after a series of murders in their small rural town of Tarker's Mills, Maine.
Just married, Papi (voiced by George Lopez) and Chloe (voiced by Odette Yustman) are trying to keep up with their five puppies Papi Jr, Lala, Rosa, Ali and Pep (voiced by Zachary Gordon, Madison Pettis, Chantilly Spalan, Delaney Jones and Emily Osment) running around the house, creating problem after problem. However, Papi shows a soft side for the pups and occasionally tells them of their ancient ancestors the Chihuahua Warriors often creating another problem. Aunt Viv (Susan Blakely), Chloe's owner, is in the rain forest for the next 6 months with her niece, Rachel (Erin Cahill) searching for plants for medical research. During this time Sam (Marcus Coloma), Papi's owner and now Rachel's boyfriend, is caring for the whole chihuahua family. Sam takes Chloe, Papi and the puppies back home to meet his parents, Mr. and Mrs. Cortez (Castulo Guerra and Lupe Ontiveros).
The film begins with the invention of a racing game called Poohsticks in which Pooh takes a walk to a wooden bridge over a river where he likes to do nothing in particular. On this day, though, he finds a fir cone and picks it up. Pooh thinks up a rhyme to go with the fir cone, but he accidentally trips on a tree root and drops it in the river. Noticing that the flow of the river takes the cone under the bridge, Pooh invents a racing game out of it. As the game uses sticks instead of cones, he calls it "Poosticks".
Teenager Angus (Bradford) finds and adopts a Yellow Labrador Retriever and names him Yellow. Several days later, while traveling along the coast of British Columbia with Angus's father, the boy and dog become stranded when turbulent waters capsize their boat. Angus's parents relentlessly badger rescue teams. Angus, schooled by his father in wilderness survival skills, and assisted by the intelligent Yellow Dog, tries to attract rescuers. Starvation, freezing temperatures, violent rainstorms, and a pack of wolves test Angus' and Yellow's courage and abilities to survive as they journey through the Canadian wilderness.
When an abandoned textile mill is reopened, several employees meet mysterious deaths. The link between the killings being that they all occurred between the hours of 11 p.m. and 7 a.m.—the graveyard shift. The sadistic mill foreman (Stephen Macht) has chosen newly hired drifter John Hall (David Andrews) to help a group clean up the mill's rat-infested basement. The workers find a subterranean maze of tunnels leading to the cemetery—and a bear-sized, hairless, bat-like creature that hunts at night. In the end, Hall is able to kill the giant bat when it gets caught in the grinding wheels of a cotton picker and crushed to death.
On the planet Dorkon, Professor Wally (the professor counterpart to Wally) shows Emperor Jon (the Emperor counterpart to Jon Arbuckle) his new invention, The Moscram ray gun, a device powered by the Klopman crystal that can scramble inanimate objects and organisms into new creatures under the user's control. But Emperor Jon is more concerned about finding a wife to continue the royal bloodline. Soon a warship lands near the palace. Emperor Jon sees Vetvix (the super-villain counterpart to Dr. Liz Wilson), and asks her if he can marry her. She agrees, but before Emperor Jon can kiss Vetvix, she plans to steal the Moscram Ray Gun, and is successful. She zombifies Emperor Jon's guards Professor Wally calls the Pet Force: Garzooka (Garfield's superhero counterpart), Odious (Odie's superhero counterpart), Abnermal (Nermal's superhero counterpart) and Starlena (Arlene's superheroine counterpart).
In present-day at New York City, an elderly woman and her granddaughter are walking through Central Park, looking for a memorial statue. As they seat themselves for a rest, the grandmother tells a story about Nome, Alaska, back in 1925 which shifts the film from live-action to animation.
Based on actual events of the early twentieth century, the story concerns a grueling 700-mile cross-country horse race in 1906 and the way it affects the lives of its various participants.
Former NYPD Captain Dewey Wilson (Albert Finney) is brought back to the force and assigned to solve a bizarre string of violent murders after high-profile magnate Christopher Van der Veer (Max M. Brown), his wife (Anne Marie Pohtamo), and his bodyguard are slain in Battery Park. Executive Security, Van der Veer's client, prefers to blame the murders on terrorists; but knowing that the victim's bodyguard was a 300-pound Haitian with voodoo ties makes Wilson skeptical. At the crime scene, Wilson meets with Warren (Dick O'Neill), his superior. With pressure to solve the case coming down from both the Police Commissioner and the Mayor, Warren partners Wilson with criminal psychologist Rebecca Neff (Diane Venora). Meanwhile, a homeless man goes exploring an abandoned church in Charlotte Street, South Bronx, which was going to be demolished by Van der Veer along with the rest of the ruined buildings in the area, to be able to build apartment complexes. He is suddenly attacked and torn to pieces by an unseen monstrous being. Wilson and Neff arrive to investigate his murder. While investigating the abandoned church, sounds of crying lure Neff up the bell tower. Wilson follows her but doesn't hear the crying; however, once Neff is separated from him, he hears a wolf howl. He goes up after Neff and drags her forcibly to safety. Later, during the night, a bridge worker is apparently murdered by the same creature.
James and Mollie, after struggling to put Mikey (now 7 years-old) and Julie (now 4 years-old) to bed, again have sex in their bedroom. She tries to refuse but he charms his way through her resistant behavior. Meanwhile outside, a pair of different breed dogs, having come from a night out are about to part ways. But the male, Trooper, instead cons the female, Princess, into mating with him after he lies and says that he is going to be fixed the next day. The screen changes for the credits of several of Trooper's sperm cells entering Princess' eggs. Their owners discover that she has given birth and decide simply to put them up for adoption.
Several years after becoming Buddy's legal owner, Josh Framm (Kevin Zegers), now a teenager, becomes angry when his mother, Jackie, begins dating Patrick Sullivan, the town's new veterinarian after a couple of failed dates. It all starts when Sullivan innocently tosses Josh's basketball-savvy dog, Buddy, a football one day, and he discovers that Buddy also has an uncanny ability to play the sport of football. Soon enough, Buddy begins playing on Josh's Junior High football team. Meanwhile, two Russian siblings by the names of Natalya and Popov kidnap Buddy in hopes of having him perform as the special attraction in the Russian circus while Josh runs away when Patrick proposes to his mother. His coach finds him and convinces him that just because Patrick is in his life now, he doesn't have to stop loving his father and he returns home, but Patrick is gone and Buddy is missing. The Timberwolves are forced to play the final game without Buddy and are unable to win. Buddy and the other animals manage to escape and Natalya and Popov are placed into the custody of the Russian embassy after their van falls into a lake following a chase sequence. Meanwhile, Patrick finds Buddy and takes him to the game. With the help of Buddy, the team catches up, but Buddy is tackled and taken out of the game. The Timberwolves are forced to finish the game without him and thanks to Josh and Tommy, they win. Later, Josh stops Patrick from leaving and convinces him to stay. The family later goes to a Seattle Seahawks football game and Buddy sneaks onto the field.
In New York Harbor, Carl Denham, famous for making wildlife films in remote and exotic locations, charters Captain Englehorn's ship Venture for his new project, but he is unable to secure an actress for a female role he reluctantly added. Denham searches the streets of New York for a suitable woman. He meets penniless Ann Darrow and convinces her to join him for the adventure of a lifetime. The Venture quickly gets underway. The surly first mate, Jack Driscoll, gradually falls in love with Ann. After weeks of secrecy, Denham finally tells Englehorn and Driscoll that their destination is Skull Island, an uncharted island shown on a map in Denham's possession. Denham speaks of something monstrous there, a legendary entity known only as "Kong".
The Turner family moves from the big city (Baltimore, Maryland) to the rural countryside in Tazewell County, Virginia, hoping to start a new life. The move creates problems for everyone, especially 13-year-old Matt (Tom Guiry), who feels lost and alone in his new surroundings. But with the help of a stray Collie dog named Lassie that the family takes in, Matt learns to adjust and the two form an unbreakable bond.
The story begins with several odd occurrences at the farm where the Black, Alec (Kelly Reno), and his mother (Teri Garr) live. A suspicious barn fire is followed by the theft of the horse. From the point of view of Ishak (Ferdy Mayne), the sheik who took him, this is property retrieval; the horse was originally his, and the Black's name is Shetan. Although he learns that the horse is being returned to the sheik's kingdom in the Moroccan desert, Alec goes after the sheik, stowing away in a plane to Casablanca.