In Mickey's Mellerdrammer, Mickey Mouse, Minnie Mouse, Goofy (known then as Dippy Dawg) and others present their own low budget light-hearted rendition of the 19th century Tom Shows for a crowd in a barn converted into a theater for the occasion.
In this short, Mickey Mouse and his friends Donald Duck and Goofy attempt to build a boat (which they name Queen Minnie), which is made from fold-out parts (the instructions simply say "All You Do Is Put It Together" and "Even A Child Can Do It"), though they encounter problems of their own as they go (e.g. Donald paints the rudder which keeps being turned by Mickey, and Goofy thinks the figurehead is an actual woman). Their maiden voyage turns out to be their last, as the boat collapses as she sets sail, thanks to Minnie Mouse hitting the champagne bottle (to christen the boat) just too hard on the boat.
After a nuclear holocaust in 2015 the survivors are divided between those who live in comfortable underground cities and the "New Primitives" who live in the sunlight. A group of these comes across a mysterious village. Despite the presence of numerous horribly mutilated corpses, the adventurers decide to settle in town after discovering a large amount of food, a greenhouse with various fruit trees and a reservoir of drinking water. The following night hundreds and hundreds of hungry genetically mutated rats are ready to attack them one by one.
The short begins with a female moose (with blond curly hair and antlers oddly enough) wading through a lake. Other odd things that make this moose strange is that she sounds her mating call with a horn and her legs are strangely familiar. The legs' owners are Donald and Goofy, disguised in a moose costume. Following them is Mickey, sounding his own moose call while being disguised as a shrub on stilts. Goofy's call is answered by an actual moose, causing him and Donald to excitedly shout " A moose!" Mickey tells them to "do their stuff" so he can shoot the moose with his shotgun. So, the duo go off to track down a moose.
Mickey Mouse and Pluto are camping in the woods about to set out hunting. Mickey reads to Pluto from an instructional book how to point at game and not move. Mickey promises that if they are successful they will have "quail on toast, and maybe a nice big juicy bear steak" that night. They then set out into the forest, Mickey carrying a shotgun.
Mickey conducts a radio orchestra who performs the Light Cavalry Overture (by Franz von Suppé). The sponsor (Pegleg Pete as Mr. Sylvester Macaroni) loves the rehearsal and agrees to have it shown in concert.
The story starts off in New York City setting sometime after the first movie (which began in 1885) presumably between 1886 and 1889, as Fievel and Tony discover that an ancient treasure lies underneath Manhattan when snooping around an abandoned subway (the Beach Pneumatic Transit system) and stumbling upon the remains of a dead mouse clutching a treasure map, deciding they must find it with the help of an archaeologist Tony knows: Dr. Dithering, along with fighting five villains as well.
Fievel, his friend, Tony and his sister, Tanya all get jobs at the local newspaper, where the audience is introduced to Nellie, who wants to be an important reporter, but only gets small assignments, as if she were a secretary to Reed, the newspaper's editor. Throughout the film, Tanya tries to win Reed's heart, while Tony tries to get noticed by Reed and promoted to a reporter. Like in the previous movies, where a mouse installation is directly below its human installation counterpart, the newspaper offices the mice work in is directly underneath the newspaper offices the humans work in.
After his usual night of drinking at the local pub, Hubert Flynn (Pete Postlethwaite) returns home and transforms into a rat. Hubert's family each have different views on him now that he became a rodent. His wife Conchita (Imelda Staunton) thinks that this change is supposed to be a lesson to Hubert and that the reason he transformed is his own fault. Their son Pius (Andrew Lovern), destined for a religious life, feels that because his father is now an animal, his family should kill him. Their daughter Marietta (Kerry Condon) feels that the rat is still her father and that they should treat him with love and respect.
On a snowy night in New York City, Jerry is comfortably asleep in his hole inside a penthouse, while Tom tries to keep from freezing to death in the alley below, after being thrown out by his owner. He writes a note, slips it into a bottle, and throws it up to hit the penthouse window. Jerry, awakened by the noise, goes out to the balcony and finds both this note and a second one sent up by Tom:
Mickey s'engage dans l'armée américaine et se rend au Viêt Nam en bateau durant la guerre. Quelques instants après son arrivée, il est descendu d'une balle dans la tête.
Mickey est joueur de piano dans un bar de la région du Klondike au Canada. Il porte secours à Minnie, choquée et à moitié frigorifiée. Arrive alors en trombe Pegleg Pierre, fraîchement descendu de son traîneau, qui après un affrontement au pistolet, kidnappe Minnie. Mickey le poursuit à bord de son traineau, trainé par Pluto. Pegleg Pierre parvient à sa cabane et s'y retranche. La bataille se poursuit, Mickey assiégeant le kidnappeur. Pendant ce temps, Pluto, qui était parti à la poursuite d'un lapin qui habite à proximité, provoque la formation d'une énorme boule de neige, qui finalement détruit la cabane et capture le ravisseur.
Mickey et son équipe de football américain, les Manglers, jouent contre les Alley Cats de Pat Hibulaire. La fin de partie est très serrée avec un 96 ex-aequo. Mickey se doit de marquer le dernier point.
Mickey et ses amis sont à une fête. Tandis que Minnie joue du piano, accompagnée de Clarabelle au violon, Mickey, Dingo et Horace sont en cuisine. Ils rivalisent d'ingéniosité pour préparer les sandwichs. À la fin du morceau de Minnie, les trois hommes amènent le repas en fanfare. Les invités se ruent sur les sandwichs et mangent en continuant à danser. Mickey invite Patricia Pig à danser. Les meubles et les aliments se mettent aussi à danser et chanter, les cotillons pleuvent et toute la maison suit la musique. Mais le vacarme attire la police, qui se mêle aux invités.