Spider Jerusalem is a fictional character and the protagonist of the comic book Transmetropolitan, created by writer Warren Ellis and artist Darick Robertson, introduced under the now-defunct Helix imprint of DC Comics before being moved to the Vertigo imprint.

He is a sarcastic, drug-addicted, foul-mouthed, troubled, bitter, but brilliant gonzo journalist with a deep-seated hatred of authority, political corruption, and dogs. Almost always drawn wearing a set of stereoscopic sunglasses with one lens red and the other green, and is most often compared to the real-life figure Hunter S. Thompson.