Frank G. Mancuso (born 25 July 1933 in Buffalo, New York) was the chairman and CEO of Paramount Pictures between 1984 and 1991, and of MGM between 1993 and 1999, when he retired.

He is currently the chairman of the Motion Picture and Television Fund Corporate Board of Directors. He is the father of executive producer Frank Mancuso, Jr.. Mancuso currently lives in Los Angeles with his wife Fay.

In 2010, Mancuso received a star on the Italian Walk of Fame in Toronto, Canada.