The film concerns a young lady named Amber, who dreams of escaping her small town existence. She therefore persuades her friends, Suzy, Peter, Fiona, Ray and Eric to accompany her to find an apartment in the big city, Chicago. Unfortunately, the vehicle transporting Amber and her friends to Chicago breaks down and as a consequence they gratefully accept a ride in the back of a semi driven by a "blatantly untrustworthy truck driver" named Bernard. However, Amber and her friends become concerned when Bernard refuses to stop and they discover that the cargo consists of hundreds of cartons of blood. Concern turns to panic and terror when Bernard ends up taking them into an abandoned meat-packing plant that is now a training ground for a group of bloodthirsty creatures. The leader of the creatures, Veronica, wants them to learn how to hunt human prey and has coaxed Bernard into helping her. Amber and her friends attempt to evade the creatures in order to survive.
Faith (Amy Shiels) is a young woman trapped in a relationship with her abusive boyfriend, Jimmy (Vance Daniels). She flees from him and moves to Atlanta to start over again. As Faith begins her new life, she meets a fun and free-spirited young woman named Lola (Lucy Holt). Lola lives on a farm with her controlling father, Jorgen (David Sterne), her older brother, and her younger brother. Faith and Lola become good friends, and Lola invites Faith to live with her and her family to help out with the farm work. During the day, the family (and Faith) work on the farm, and at night the two young women go out on the town to party in Atlanta. Lola brings home a different man every night. Eventually Faith notices that these men disappear after their encounters with Lola, and she suspects that Lola's father is murdering them in the farm's slaughterhouse.
It is modern day and a young girl is running through the forest and runs into her house, trying to get away from something. It turns out it was just a dream that the young girl was having. Her mother comes in to remind her that she is going to go and stay with her father for the weekend.
It’s been 5 years since the outbreak that wiped out 85% of the world’s population, but the war between Re-Animates (Re-Ans) and Humans wages on. Most of the major cities are still uninhabitable. Within the few surviving cities, the Re-Ans have been segregated into “zones” and are policed by the R-Division of the QUASI S.W.A.T. Unit who hunt to re-kill the Re-Ans in the hope of quelling a second outbreak.
The film begins with a man going into a church. He enters the confessional booth where he tells the priest he would like to make a donation to the church, but before the father can accept, the man shoots himself in the head.
The film opens up with an armored truck coming across a car accident in the middle of a road. The driver finds this suspicious and prepares to drive off, but the truck is suddenly attacked by masked robbers. The driver tries to make a break for it, but his partner is revealed to be in on the heist. They execute the driver when an alarm in the truck goes off, and then his partner when he questions the lead robber's motives.
St. Jude Square is a neighborhood living in fear and despair. The dueling gangs of local kingpins, Dash and Antoine, terrorize the streets, and the citizens live without a shred of hope until mysterious stranger, Ryan Hong (Cung Le) arrives. He begins to play one gang against the other, by calling on the teachings of his mentor, Tiano (Jean-Claude Van Damme), to find the strength to battle back. However, just as he begins to bring the community under control, Hong is confronted by Mr. V (Peter Weller), the town's corrupt police chief. At first Mr. V is impressed by Hong's skill, but soon sees Hong as a threat to his regime and the two are locked in a head to head battle, pitting the fear and corruption of Mr. V's regime against the new beginning Hong represents for the people of St. Jude Square.
Emily (Leisha Hailey) and Nate Weaver (Gale Harold) are a happily married couple living in New York. Nate is a recognized artist, Emily a fashion designer, and the two are expecting their first child. Emily suffers a terrible miscarriage during a dinner party and she is informed that the scarring left on her womb means she will never be able to conceive again.
Political and public pressure coerces the government into allowing two well-known reporters and their assistants limited access to the ultra-secretive Area 51. The group consists of 20-year news veteran Sam Whitaker; his camera-woman Mindy; Claire Fallon, an ambitious writer, journalist, and head of an acclaimed news blog called The Fact Zone; and her cameraman Kevin. The four tour the base and things go well for a while, but when one of the base's "occupants" attempts to liberate both himself and those of his fellow species, Area 51 changes from being a secured government facility to a place of horror.
An archeology professor (Lauren Holly) unearths a dangerous artifact, unwittingly releasing a creature that is able to kill with the power of its bone-splitting scream. It can kill by controlling the person and taking the person's soul.
A teenage girl is shown to be evidently disfigured when she visits a restaurant and gains the attention of surrounding people. Her emotional outburst flashes the story back to show how her situation unraveled. In high school, a boy named Ravi (Vincent Silochan) is bullied and insulted by two jocks, Bradley (Justin Arnold) and Bernard (Daniel Ross). Goth girl, Emily (Lindsay Seidel), is taunted by a group of three popular girls named Heather (Julin), Bridget (Whitney Hoy), and Kelli (Laura Ashley Samuels), who abuse her despite her pleas for friendship. Dane (Marc Donato) is another outcast who inherited an old, secluded house in the woods from his late uncle's will.
The film concerns a young lady named Amber, who dreams of escaping her small town existence. She therefore persuades her friends, Suzy, Peter, Fiona, Ray and Eric to accompany her to find an apartment in the big city, Chicago. Unfortunately, the vehicle transporting Amber and her friends to Chicago breaks down and as a consequence they gratefully accept a ride in the back of a semi driven by a "blatantly untrustworthy truck driver" named Bernard. However, Amber and her friends become concerned when Bernard refuses to stop and they discover that the cargo consists of hundreds of cartons of blood. Concern turns to panic and terror when Bernard ends up taking them into an abandoned meat-packing plant that is now a training ground for a group of bloodthirsty creatures. The leader of the creatures, Veronica, wants them to learn how to hunt human prey and has coaxed Bernard into helping her. Amber and her friends attempt to evade the creatures in order to survive.
The film begins with a teenage girl, Natalie (Rumer Willis) sitting with her boyfriend Sean as he reads from a black book. He finishes reading, and kisses Natalie passionately. Natalie believes he wants to have sex with her – until he pulls out a gun and commits suicide.
Sam Reide (Chris Carmack) witnesses a woman being killed, then wakes up in an ice-filled bathtub, his vitals being monitored by his sister Jenna (Rachel Miner). Sam can travel back to any time and location during his lifetime (occupying the body of that time in his life), needing only to concentrate on where and when he wishes to arrive. He has helped the local police capture criminals under the guise of being a psychic. We learn that Sam pays his sister Jenna's rent and buys her groceries, and that she rarely leaves the apartment and lives in squalor.
At a small college, Quaid and his friend Stephen do a "fear study" as a school project, recording people talking about their greatest fears. Quaid however is quite insane and wants to take the fear to 'the next level'. Quaid had seen his parents killed by an axe murderer as a child; this is his greatest fear, and he wants to learn what makes others afraid and what it takes for them to overcome their fear. Stephen's brother had died while drunk-driving, and Stephen wonders if his brother would still be alive if he had driven instead.