Après une rencontre fatidique avec un mystérieux étranger, Pee-wee Herman prend ses toutes premières vacances dans ce conte épique sur le thème de l’amitié et du destin.
Gordon Townsend (Colin Quinn) is telling his two young daughters Amy (Devin Fabry) and Kim (Carly Oudin) that he and their mother are divorcing because monogamy isn't realistic. Twenty-three years later, Amy (Amy Schumer) is a party girl who drinks too much, smokes weed and sleeps around while dating a gym-addict named Steven (John Cena).
Dan Mulligann (Mark Ruffalo) is a formerly successful record label executive living in New York City who is estranged from his wife Miriam and struggling to keep up with the changing music industry. After being fired from his job, he goes on a drinking binge which leads him to a bar in the Lower East Side where he encounters Gretta James (Keira Knightley). Gretta is a young and fiercely independent songwriter who has just broken up with her long-time boyfriend and songwriting partner Dave Kohl (Adam Levine), a newly successful musician who had an affair with one of his producers' assistants. Captivated by Gretta's music, Dan offers to sign her to his former record label, and although she initially refuses she reconsiders the offer and agrees.
In 1980, Ron Burgundy (Will Ferrell) and Veronica Corningstone (Christina Applegate) are married and are both co-anchors for a prestigious news network in New York City. One day, Mack Tannen (Harrison Ford), the most famous nightly news anchor in New York, reveals that he is retiring. He intends to promote Corningstone, making her the first female nightly news anchor in the history of television, and to fire Burgundy due to his continuously sloppy performance on air. Burgundy grows jealous of Corningstone's success and storms out of the house, leaving Corningstone and his six-year-old son Walter (Judah Nelson).
The film begins with couple Debbie (Leslie Mann) and Pete (Paul Rudd), first seen in Knocked Up; they are having sex on Debbie's 40th birthday. Pete reveals that he took a Viagra given to him by his friend Barry (Rob Smigel); this enrages Debbie and they stop. Debbie is angered that she is turning 40.
Tom Solomon (Jason Segel), a sous chef at a fancy restaurant, and Violet Barnes (Emily Blunt), a psychology PhD graduate, are a happy couple in San Francisco who get engaged a year after they began dating. Their nuptials get interrupted when Tom's best friend Alex Eilhauer (Chris Pratt) gets Violet's sister Suzie (Alison Brie) pregnant at Tom and Violet's engagement party and the two marry before Tom and Violet. Their nuptials get further delayed when Violet gets accepted into the University of Michigan's post-doctorate in psychology program which lasts two years. Tom agrees to move with her and delay their wedding until then. However, when he tells his boss, he becomes disheartened when she states she was planning on making him head chef at a new restaurant in town.
George and Linda Gergenblatt are an urban married couple who purchase a micro-loft in New York after much hesitation. George is expecting a promotion while Linda is trying to sell a documentary to HBO. Soon after purchasing their home, George learns that his company has folded, overnight, while HBO rejects Linda's documentary. With both out of work, they are forced to sell their apartment and drive to Atlanta to live with George's arrogant brother Rick and his wife Marisa after Rick offers George a job.
Annie Walker (Kristen Wiig) is a single woman in her late 30s. Following the failure of her bakery, she lost her boyfriend and her savings, forcing her to take a job as a sales clerk in a jewelry store and to share an apartment with an obnoxious roommate Gil (Matt Lucas) and his sister Brynn (Rebel Wilson). Her business's failure was so painful that she has given up baking entirely. She has a no-strings-attached sexual relationship with the self-absorbed Ted (Jon Hamm) but hopes for something more from him. Her best friend, Lillian (Maya Rudolph), is virtually her only source of happiness.
In 2008, British cheeky chappy rock star Aldous Snow (Russell Brand) releases an album and a titular single — "African Child", which is a commercial and critical failure. In an interview, despite having been teetotal and free of drugs, along with his pop-star girlfriend Jackie Q (Rose Byrne), she drunkenly declares they have a boring life in an interview. He relapses — which effectively ends his relationship with her, makes him lose custody of their son, Naples, sabotages his career and makes him become a slacker. Meanwhile, in Los Angeles, Aaron Green (Jonah Hill) works as a talent scout at Pinnacle Records, a successful record company. He lives with his girlfriend, Daphne (Elisabeth Moss), a doctor. Pinnacle Records is performing badly as a result of poor record sales, and the head of the company, Sergio Roma (Sean Combs), asks for ideas. Green proposes that Aldous Snow play at the Greek Theatre in Los Angeles on the tenth anniversary of his legendary performance there in 1999.
Zed (Jack Black) is a hunter and Oh (Michael Cera) is a gatherer. After being informed that Zed ate from the Tree of Knowledge of Good and Evil, the shaman (Bill Hader) and Marlak (Matthew Willig) banish him from the tribe. After Zed burns down the village by accident, Oh decides to go with Zed on his journey to discover all the world has to offer. Along the way, they encounter Cain and Abel (David Cross and Paul Rudd). Cain kills Abel and informs Zed and Oh that they must escape with him or else be accused of killing Abel.
George Simmons (Adam Sandler) is a middle-aged former stand-up comedian turned movie star. Despite his millions he is sad and lonely and most of his recent film work is low-brow and dumb. He is diagnosed with acute myeloid leukemia and offered an experimental treatment that has only an eight-percent chance of therapeutic response. Believing he is about to die, he returns to his roots to do stand-up comedy.
On the first day of high school, Wade and Ryan witness two bullies, Filkins and Ronnie, attack a geek, Emmit, by stuffing him into his locker. Wade intervenes. Filkins and Ronnie begin endlessly targeting Wade, Ryan and Emmit.
Dale Denton (Seth Rogen) is a 25-year-old process server and habitual pot smoker. He makes a visit to the home of his drug dealer, Saul Silver (James Franco), to buy weed. Saul tells him that he may already know the identity of Dale's next service, Ted Jones (Gary Cole). Dale drives to Ted's house and witnesses Ted and a cop, Officer Carol Brazier (Rosie Perez), shoot an Asian man to death. Dale panics and flees the area, but leaves his roach at the scene which contains a rare strain of marijuana called Pineapple Express. Ted is able to identify the strain and sends his two henchmen, Budlofsky and Matheson (Kevin Corrigan and Craig Robinson) to dealer Red (Danny McBride), who tells them that he has only sold the pot to Saul.
39-year-old Brennan Huff (Will Ferrell) and 40-year-old Dale Doback (John C. Reilly) are two unemployed, middle-aged, spoiled, offensive, and self-centered men who still live with (and are reliant on) their parents. They have no intention of moving out or finding jobs and behave childishly. When Brennan's mother Nancy (Mary Steenburgen) and Dale's father Robert (Richard Jenkins) marry, Brennan and Dale are forced to live with each other as step brothers.