Seven Tulane University undergraduates – Sara, Nick, Beth, Malik, Maya, Blake and Gordon – drive to Sara's family vacation home on a private lake. There, Sara encounters her old boyfriend, Dennis, and his friend Red.
In Villach in the 13th century, three women are accused of witchcraft by a priest. While one claims to be a witch through persuasion from the church, one doesn't deny it and curses the priest. He orders them hanged and drowned. That done, he urges the guards to pull them back up for a ritual to make sure the so-called witches never come back to life. The guards refuse, claiming they are dead enough. The priest returns late at night to perform the ritual. The third corpse takes on a demonic appearance and kills the priest.
Family man Abel Plenkov (Raul Esparza), a sufferer of schizophrenia, accidentally discovers that he is the Riverton Ripper, a local, masked serial killer. After killing his pregnant wife, Sarah (Alexandra Wilson), and then his psychiatrist, he is shot down and carted away in an ambulance, leaving his young daughter Leah and premature son orphaned. On the way to the hospital, a paramedic (Danai Gurira) suggests that Plenkov himself is innocent but that he houses multiple souls, with the Ripper's being one of them. Near death, Plenkov unexpectedly revives, slashing the paramedic in the throat, causing the ambulance car to crash and burn and seemingly escapes.
In the 19th century, a warrior named Yang (Jang Dong-gun) is ordered to kill the last member of an enemy clan—a baby. He refuses the mission and flees with the child to a dilapidated town in the American West. Despite his attempts, his master closes in on him and he must fight to protect the child and his newfound comrades: Ron (Geoffrey Rush), the town drunk, and Lynne (Kate Bosworth), both of whom have a tragic past.
A young mild-mannered American couple, Cliff (Zahn) and Cydney (Jovovich), are celebrating their marriage by hiking to a remote beach in Hawaii while on their honeymoon. On their way, they see two hitchhikers, Cleo (Shelton) and Kale (Chris Hemsworth). They offer the pair a ride but change their minds when the two seem possibly dangerous.
Emma (Monica Potter) and John Collingwood (Tony Goldwyn), and their daughter, competitive swimmer Mari (Sara Paxton), head out on vacation to their lake house. Shortly thereafter, Mari borrows the family car and drives into town to spend some time with her friend Paige (Martha MacIsaac). While Paige works the cash register at a local store, she and Mari meet Justin (Spencer Treat Clark), a teenager passing through town who invites them both back to his roadside motel room to smoke some marijuana. While the three are hanging out in the motel room, Justin's family members return: Krug (Garret Dillahunt), Justin’s father; Francis (Aaron Paul), Justin’s uncle; and Sadie (Riki Lindhome), Krug’s girlfriend.
Present day New York City: Sean MacArthur (Channing Tatum) is a street hawker. One day while selling counterfeit goods at the corner of Radio City Music Hall, a group of young men attempt to force Sean to relocate with his merchandise. These boys work for Harvey Boarden (Terrence Howard), a ticket scalper who controls the corner. Sean fights them off, but does not retain his money or products.
Casey Beldon has nightmarish hallucinations of strange-looking dogs in the neighbourhood and an evil child with bright blue eyes following her around. While babysitting Matty, her neighbor's son, she finds him showing his infant sibling its reflection in a mirror. Matty attacks Casey, smashing the mirror on her head, and tells her: "Jumby wants to be born now". She puts him to bed and leaves in shock.
The film begins in medias res with a recorded 911 call of a boy screaming that he and his friend found two bodies lying in blood in an old vacation house.
Jim Halsey and Grace Andrews are driving across New Mexico on spring break. At night, a hitchhiker stands in the middle of the road, near his broken down car. Jim nearly hits him and his car spins out of control. Grace insists that someone else will stop to help him and they speed off.
Eleven year old Randy Daytona becomes anxious when he learns that his father Peter has bet on his performance in the 1988 Summer Olympics table tennis finals. During his first game between his opponent Karl Wolfschtagg from the German Democratic Republic, Daytona has an accident and suffers an injury. Unable to continue, he loses the match. Loan sharks in the employ of criminal mastermind Feng murder his father, and Daytona leaves competitive ping-pong.
Police Constable Nicholas Angel, a high-achieving member of the Metropolitan Police Service, is promoted to Sergeant but it comes with being transferred to the village of Sandford, Gloucestershire, for being too good at his job while making his colleagues look bad by comparison due to his skills. Angel finds the town is generally devoid of any crime, with its local Neighbourhood Watch Alliance (NWA) helping to keep the peace as everyone prepares for the "Village of the Year" award contest. Angel finds minor instances of disorderly conduct, during which he confiscates a shed full of unlicensed fire arms including a naval mine, pursues an escaped swan, and arrests a drunk driver who turns out to be his new partner PC Danny Butterman, the son of town chief Inspector, Frank Butterman.
After witnessing the murder of his wife and young son at the hands of Henry Caine (Craig Fairbrass), who then turned the gun on himself, Abe Dale (Nathan Fillion) is so distressed that he attempts to take his own life. A near-death experience follows that leaves Abe with the ability to identify those who are about to die. He acts on these premonitions to save three people from death, among them a nurse met during his recovery, Sherry Clarke (Katee Sackhoff).
Ex-con Otis (Tyrese Gibson), or "O2" as he was once known on account of his ability to vanish from a crime scene like oxygen, has done his time and is now determined to stay out of trouble and never leave his young son, Otis, Jr. (played by Vondie Curtis-Hall's young son, Henry Hunter Hall), ever again.
Erik Stifler (John White) has a difficult time living up to his family name. He is Steve and Matt Stifler's cousin. He is perhaps the only Stifler about to graduate from high school as a virgin. The film opens with Erik feigning illness so that he can stay home and masturbate. Unfortunately, just as he is about to ejaculate, his parents and grandmother unexpectedly walk into the door and are hit with Erik's semen, after which his grandmother dies of a heart attack. Erik's dad later surmises that, as a Stifler, his son should be out having sex instead of masturbating. Erik's girlfriend of two years, Tracy (Jessy Schram), loves him, but is not ready for intercourse. Tracy decides to have sex, their first attempt goes horribly wrong, and she backs out of trying again.