Osmosis Jones (2001)

Osmosis Jones is a 2001 American live-action/animated buddy cop comedy film directed by Tom Sito and Piet Kroon for the animated segments and the Farrelly brothers for the live-action ones. Unusual in this genre, the animated characters are inside the live-action ones. It is set in a fictionalized version of the human body which resembles a large city, where micro-organisms or any being based in organisms are anthropomorphic and centers on Frank Detorre, a slovenly zookeeper. Osmosis Jones, a white blood cell, teams up with Drix, a cold pill, against Thrax, a deadly virus who plans to kill Frank in forty-eight hours and other characters living within him.

It met with mixed reviews, and was a box office bomb, earning $14 million against a budget of $70 million. Despite the lack of accolades, the film sold well in home media. It also served as the pilot to the television series Ozzy & Drix, which aired on Kids' WB from 2002 to 2004, albeit being completely animated and more emphasis on Osmosis and Drix's partnership in a different body.

Synopsis

Frank Detorre (Bill Murray) is a widowed slovenly zookeeper at the Sucat Memorial Zoo in Rhode Island. Much to the frustration of his young daughter, Shane (Elena Franklin), he eats compulsively unhealthy and has minimal concern for germs or disease. While trying to eat a hard-boiled egg with mayonnaise and salt, it is stolen from him by a chimpanzee. He gets it back, but not before it falls into the filth of the chimp's habitat. When Shane is disgusted by him about to eat it he uses the "ten second rule" as a justification for the unsanitary act.

Actors