After letting Dominic Toretto escape from the authorities, Brian O'Conner leaves his home in Los Angeles in his modified Mitsubishi 3000 GT VR-4 before LAPD and the FBI launch a national manhunt on him. While on the run, he makes a living out of winning street races in Phoenix, Arizona, and Albuquerque, New Mexico. One night at a motel, Brian is forced to abandon his car when the local police surround it. He manages to hitch a ride from a woman in a Mitsubishi Eclipse Spyder and is dropped off at a used car lot in San Antonio, Texas, where he buys a Nissan Skyline GT-R R34 in poor condition. Brian rents out a garage to modify the car before using it to win more races. Arriving in Miami he sees Slap Jack's Toyota Supra and Orange Julius' Mazda RX-7 before the screen reads "2 be continued.
A race-car driver whose career is on the skids because of his drinking falls for a rich society girl. That motivates him to clean up his act and resume his career, but it may be too late for that.
Billy Coy (Mickey Rooney) from Carrell in California wants to be a race car driver. He manages to get hired as a mechanic by Arthur "Red" Stanley (Thomas Mitchell) at his garage, after mentioning that he is the son of a famous driver called "Cannonball" Coy. Billy's father died in an accident at the Indianapolis 500 a few years ago.
Countess Diana Gaston (Patricia Roc) meets Vittorio Serra (Massimo Serato), the grandson of Carlo Serra, a prominent businessman. Convinced that she has met the man for her, she does all she can to keep him in her life. Unfortunately both of them are self-centered and this leads to repeated conflict. Vittorio's passion for auto racing leads to continued diagreements between him and the countess.
Before a major motor race in Italy a man is hired by a British racing team to headhunt the designer of a rival team. However, when he fails, he attempts to steal the team's designs instead. When he is disturbed in the middle of the theft, he is forced to shoot his way out, killing five people. The head of British team plans to cover up the crime by using the race to smuggle the man out the country.