Following a nuclear holocaust, the world has become a desert wasteland and civilization has collapsed. Max Rockatansky, a survivor, is captured by the War Boys, the army of the tyrannical Immortan Joe, and taken to Joe's Citadel. Designated a universal blood donor, Max is imprisoned and used as a "blood bag" for a sick War Boy called Nux. Meanwhile, Imperator Furiosa, one of Joe's lieutenants, is sent in her armored truck, the "War Rig", to collect gasoline. When she drives off-route, Joe realizes that his five wives—women selected for breeding—are missing. Joe leads his entire army in pursuit of Furiosa, calling on the aid of nearby Gas Town and the Bullet Farm.
In 2003, Dr. Serena Kogan (Helena Bonham Carter) of Cyberdyne Systems convinces death row inmate Marcus Wright (Sam Worthington) to sign over his body for medical research following his execution. One year later, the automated Skynet system is activated, begins to perceive humans as a threat, and eradicates much of humanity with nuclear weapons in the event known as "Judgment Day".
A race of extraterrestrials called Mimics has taken over continental Europe. In England, General Brigham, head of humanity's United Defense Force, orders Major William Cage, a public affairs officer with no combat experience, to cover the next day's amphibious assault in France. Cage objects to the dangerous assignment and threatens to blackmail Brigham to avoid it. Brigham has Cage arrested; Cage is knocked out trying to escape. He wakes in handcuffs at a forward operating base at Heathrow Airport and discovers he has been demoted to private, charged with desertion, and assigned to a combat squad named "J" squad under the command of Master Sergeant Farell.
As a young boy, Noah witnesses his father, Lamech, killed by a young Tubal-cain. Many years later an adult Noah is living with his wife Naameh and their sons Shem, Ham, and Japheth. After seeing a flower grow instantly from the ground and being haunted by dreams of a great flood, Noah takes them to visit his grandfather Methuselah.
In 2029, aboard the United States Air Force space station Oberon, Leo Davidson works closely with primates who are trained for space missions. His favorite simian co-worker is a chimpanzee named Pericles. With a deadly electromagnetic storm approaching the station, a small space pod piloted by Pericles is used to probe the storm. Pericles's pod heads into the storm and disappears. Against his commanding officer's orders, Leo takes a second pod and goes in pursuit of Pericles. Entering the storm, Leo loses contact with the Oberon and crashes on a planet called Ashlar in the year 5021. He discovers that the world is ruled by humanoid apes who can speak human language and treat human beings as slaves.
On July 20, 1969, astronaut Jim Lovell hosts a party, where guests watch on television as Neil Armstrong takes his first steps on the Moon during Apollo 11. After the party, Lovell, who had orbited the Moon on Apollo 8, tells his wife Marilyn that he intends to walk on the Moon's surface.
Los Angeles SWAT officers Jack Traven and Harry Temple thwart an attempt by a bomber to hold an elevator full of people for a $3 million ransom. They corner the bomber, but he grabs Harry. Jack shoots Harry in the leg, forcing the bomber to release him. He turns and runs around a corner, apparently dying in an explosion. Jack and Harry are praised by their superior, Lieutenant "Mac" McMahon.
On May 10, 1998, teenage amateur astronomer Leo Biederman discovers an unusual object near the stars Mizar and Alcor at a star party in Richmond, Virginia with his school's astronomy club. His teacher alerts astronomer Dr. Marcus Wolf, who realizes that the object is a comet on a collision course with Earth. Wolf dies in a car accident before he can alert the world.
A 16-year-old boy wakes up inside an underground service elevator with no memory of his identity. A group of male youths greet him in a large grassy area called the Glade that is enclosed by tall, stone walls. Every month, a new boy and supplies arrive in the elevator. The boys, who call themselves Gladers, have formed a rudimentary society with each assuming specialized tasks. Alby, their leader and the first to arrive in the Glade, says every boy eventually recalls his name, but none remember their past. The boy learns that a vast Maze surrounding the Glade may provide the only way out. During the day, designated Runners search the Maze for an escape route, returning before nightfall when the entrance closes. No one has ever survived a night inside the Maze.
In October 1991, the commercial fishing boat Andrea Gail returns to port in Gloucester, Massachusetts, with a poor catch. Desperate for money, Captain Billy Tyne (Clooney), convinces the Andrea Gail crew to join him for one more late season fishing expedition. The crew heads out past their usual fishing grounds in the Grand Banks, leaving a developing thunderstorm behind them. Initially unsuccessful, they head to the Flemish Cap, where their luck improves. At the height of their fishing the ice machine breaks; the only way to sell their catch before it spoils is to hurry back to shore. After debating whether to sail through the building storm or to wait it out, the crew decides to risk the storm. However, between the Andrea Gail and Gloucester is a confluence of two powerful weather fronts and a hurricane, which the Andrea Gail crew underestimates.
In the small town of Oakey Oaks, Chicken Little rings the school bell and warns everyone to run for their lives, allowing the whole town into a frenzied panic with much damage ensuing. Eventually, the Head of the Fire Department calms down enough to ask him what's going on and Little explains that a piece of the sky shaped like a stop sign had fallen on his head when he was sitting under the big oak tree in the town square; however, he is unable to find it. His father, Buck Cluck, assumes that this "piece of sky" was just an acorn that had fallen off the tree and had hit him on the head, making Little the laughing stock of the town.
Picking up immediately after the events in Resident Evil: Retribution, humanity is on its last legs after Alice is betrayed by Wesker in Washington D.C. As the only survivor of what was meant to be humanity's final stand against the undead hordes, Alice returns to where the nightmare began, Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse. In a race against time, Alice joins forces with old friends, and an unlikely ally, in a battle with undead hordes and new mutant monsters. Between losing her superhuman abilities and Umbrella's impending attack, this will be Alice's most difficult adventure as she fights to save humanity.
In 2005, scientists discover an extrasolar planet, which they name Planet G, with conditions similar to Earth. In 2006 NASA transmits a powerful signal from a communications array in Hawaii. Meanwhile, slacker Alex Hopper gets arrested while attempting to impress Sam Shane, daughter of U.S. Pacific Fleet commander Admiral Terrance Shane. Stone Hopper, Alex's older brother and a naval officer, is infuriated at Alex's lack of motivation and forces Alex to also sign up and earn a commission in the U.S. Navy.
As Reed Richards and Sue Storm prepare for their wedding, a silver object enters Earth's atmosphere, creating 1 mile wide craters across the Earth. General Hager asks Reed to track and identify its movements. He initially refuses, to appease Sue, who feels he is again neglecting her for his work. However, he secretly builds a radar tracker to locate the object, as the Army requests.