Second Skin examines people whose lives have been transformed by virtual worlds in online games such as World of Warcraft, Everquest, Everquest II and Second Life. The documentary follows a group of online gamers whose lives are intensely woven together inside and outside the virtual worlds, a couple whose lives have changed since meeting online, and an avid player whose life spins out of control due to his addiction to playing MMOs. It also presents disabled players who have been given voice and mobility in the virtual world and explores the controversial world of Chinese gold farming and presents facts about online gaming.
The plot, which takes place in an alternate storyline between the events of Tekken 5 and Tekken 6, begins with Anna Williams setting up a decoy for her sister, Nina Williams, who is currently working with the new head of the Mishima Zaibatsu, Jin Kazama. Anna, on the other hand, works for Jin's father, Kazuya Mishima and its rival organization, G Corporation. Both are seeking information about a student named Shin Kamiya, and Anna dispatches a Chinese student, Ling Xiaoyu to act as a spy, while Jin sends humanoid robot Alisa Bosconovitch for a similar purpose.
Alessandro is an Italian teacher who is determined to be a good father for his teenage daughter Irina. This is impeded by Alessandro's brother Crampone who lives in the same household and who never ceased to foster revolutionary political ideas.
The film focuses on the history of computer company Apple Inc., and its Macintosh line of computers specifically. It discusses the company's employees, philosophy, practices, and interviews people who were working at Apple when the Macintosh was first released.
The film details the experiences of "the greatest Internet pioneer you've never heard of," Josh Harris. The dot-com millionaire founded Pseudo.com, the first Internet television network during the infamous tech boom of the late '90s. After achieving prominence amongst the Silicon Valley set, Harris became interested in controversial human experiments which tested the effects of media and technology on the development of personal identity. Ondi Timoner documented the major business-related moments of Harris's life for more than a decade, setting the tone for her documentary of the virtual world and its supposed control of human lives.
Rayne fights against the Nazis in Europe during World War II, encountering Ekart Brand, a Nazi leader whose target is to inject Adolf Hitler with Rayne's blood in an attempt to transform him into a dhampir and attain immortality.
Researchers conduct secret and illegal experiments using stem cells. The researchers accidentally discover a serum derived from these stem cells capable of reviving dead cellular tissue. When a security guard, David Doyle, is injured while working and threatens to sue the research company, he is promptly murdered and used as a test subject.