Following the events of Alien vs. Predator, a Predator ship is leaving Earth carrying Alien facehuggers, and the body of Scar, the Predator that defeated the Alien Queen. A chestburster erupts from Scar's body; it is a new creature that is a hybrid of both species. It quickly matures into an adult Predalien and starts killing all the Predators on the ship. A Predator's weapon fire punctures the hull and the ship crashes in the forest outside of Gunnison, Colorado.
A group of vampires look for the hidden resting place of Drake, also known as Dracula—the genetic "father" of their species. They find him in a Syrian ziggurat tomb, although not before, in a moment of blood lust, he kills one of them. The vampires capitalize on Blade's reputation as a serial killer and frame him for the killing of a familiar. During the ensuing manhunt, the FBI locate Blade's latest hideout, and, during the siege, Abraham Whistler dies. With his mentor gone and surrounded by human authorities, Blade allows himself to be captured and arrested.
By the 2080s, much of Earth has become an uninhabitable wasteland. While some humans manage to survive in the wasteland, the majority of humanity resides in huge Mega-Cities with populations of tens of millions, where the traditional justice system has been replaced by a corps of Judges whose role combines those of police officer, judge, jury, and executioner. The most dedicated "Street Judge" in Mega-City One is Joseph Dredd (Sylvester Stallone), who assists rookie Judge Hershey (Diane Lane) in ending a block war. Herman "Fergee" Ferguson (Rob Schneider), a hacker recently released from prison, is caught in the firefight and hides inside a food dispensing robot, only to be arrested by Dredd and again sentenced to five years' imprisonment.
Riggan Thomson (Michael Keaton) is a faded Hollywood actor best known for playing the superhero Birdman decades ago in a series of films. He is often tormented by the mocking, critical inner voice of Birdman, and frequently visualizes himself performing feats of levitation and telekinesis. The film opens with a quotation from Raymond Carver stating that the main fulfillment in life is related to having once been loved, then cuts to a dramatic atmospheric disturbance resembling a meteor descending in flames. The film then cuts to a surreal shot depicting Riggan as levitating in his stage room. Riggan hopes to reinvent his career by writing, directing, and starring in a Broadway production of a loosely based adaptation of Carver's short story "What We Talk About When We Talk About Love".
In 1863, Confederate soldiers are carrying a gold bullion as a payday for the army. Suddenly, they are cornered and shot by a highwayman using anachronistic machine pistols and futuristic tech equipment, leaving them stranded and dead before suddenly vaporizing into the mist.
In the Southeast Asian nation of Shadaloo City, civil war has erupted between the forces of crazed military dictator General M. Bison (Raul Julia) and the Allied Nations, a multinational military force, led by their regional commander, Colonel William F. Guile. Bison has recently captured several A.N. relief workers, and via a live two-way radio broadcast, demands Guile secure a US$20 billion ransom in three days or else face responsibility for the hostages' deaths. Guile refuses and vows to track Bison down, but his assistant, Sergeant Cammy (Kylie Minogue) is only partially able to pinpoint Bison's location to the river-delta region outside the city. One of the hostages is Guile's close friend, Carlos "Charlie" Blanka (Robert Mammone), who Bison orders taken to his lab for his captive witch doctor, Dhalsim (Roshan Seth), to turn into the first of his supersoldiers. Though Charlie is severely disfigured by the procedure, Dhalsim secretly alters his cerebral programming to maintain Charlie's humanity.
In 1944, the Nazis build a dimensional portal off the coast of Scotland. With the help of Russian mystic Grigori Rasputin, they intend to free the Ogdru Jahad—monstrous entities imprisoned in deep space—to aid them in defeating the Allies. Rasputin knows this will be an apocalyptic event that he believes will create a paradise. He opens the portal with the aid of his disciples, Ilsa von Haupstein and Obersturmbannführer Karl Ruprecht Kroenen, member of the Thule Society and Adolf Hitler's top assassin. An Allied team is sent to destroy the portal, guided by young Trevor Bruttenholm, who is well-versed in the occult. The German team is killed and the portal is destroyed—in the process absorbing Rasputin—while Haupstein and Kroenen escape. The Allied team discovers that an infant demon with a right hand of stone came through the portal; they dub him "Hellboy" and Bruttenholm adopts him.
Dave Lizewski (Aaron Johnson) is an ordinary teenager who lives in Staten Island, New York. Dave purchases a bodysuit and makes modifications to it. He then embarks on a campaign to become a real-life superhero, armed with a couple of batons. During his first attempt to fight crime, he becomes the victim of a stabbing and a hit and run. This leaves him with multiple fractures and metal plates, all of which cause him to require extensive rehabilitation. In the process of recovery, he gains a capacity to endure pain and enhanced durability. In his absence from school, a rumor spreads that he is gay, as he was found naked by the paramedics after discarding his costume. As a result, his longtime crush, Katie Deauxma (Lyndsy Fonseca), immediately attempts to become his friend.
Three thousand years ago, an Aztec warlord named Yaotl and his four generals discover a portal opening into a parallel universe which is said to have great power. Yaotl becomes immortal but at a high price, as his four generals were turned to stone. The portal releases thirteen immortal monsters that destroy his army as well as his enemies. In the present, the Teenage Mutant Ninja Turtles have grown apart. After defeating the Shredder, Master Splinter has sent Leonardo to Central America for training. Donatello works as an IT specialist, Michelangelo works as a birthday party entertainer called Cowabunga Carl and Raphael works at night as a vigilante nicknamed Nightwatcher. April O'Neil operates a company that locates and acquires relics for collectors with the help of her boyfriend, Casey Jones.
On October 30, Devil's Night in Detroit, Sergeant Albrecht is at the scene of a crime where Shelly Webster has been beaten and raped, and her fiancé Eric Draven then died on the street outside, having been stabbed, shot, and thrown out of the window. The couple were to be married the following day, on Halloween. As he leaves for the hospital with Shelly, Albrecht meets a young girl, Sarah, who says that she is their friend, and that they take care of her. Albrecht tells her that Shelly is dying.
Al Simmons (Michael Jai White) is a special forces agent and black ops soldier. Jason Wynn (Martin Sheen), head of the covert government agency for which Simmons works, assigns him to infiltrate a biochemical weapons plant in North Korea. Unbeknownst to Simmons, Wynn has ordered his top assassin, Jessica Priest (Melinda Clarke), to murder him while he is on his mission. After Simmons dies in a gas fire, he arrives in Hell, where the demon king Malebolgia (Frank Welker), offers him a Faustian deal: if Simmons becomes his eternal servant and leader of his army in Armageddon, he will be able to return to Earth to see his fiancée, Wanda Blake. Simmons accepts the offer and returns to Earth.
Will Stronghold (Michael Angarano) is beginning grade nine at Sky High, a high school that teaches super powered children. Will's parents are The Commander (Kurt Russell) and Jetstream (Kelly Preston), the world's most famous superheroes. Will's best friend is Layla (Danielle Panabaker), who has the power to manipulate plant life.
Scientist Rohit Mehra lives with his son Krishna "Krrish" Mehra (both played by Hrithik Roshan) in Mumbai. Krishna is married to Priya (Priyanka Chopra) who works as a journalist for Aaj Tak. Rohit works in a research institute for the Indian government and Krishna, while moon lighting as the superhero Krrish, is regularly fired from various day jobs due to lack of attendance. Rohit is researching on a device that will bring life to dead tissues by the use of solar energy. Despite several attempts, he fails to complete the experiment due to the high intensity of sun rays. On a usual day, Krishna loses his job from the security wing of a company when he hears news about an aeroplane whose front tyres are stuck due to some malfunctioning which creates high risk, even if landed, it may explode and so will the passengers inside. Krishna immediately changes himself to Krrish and saves the plane from accident by holding the component to make tyres free to roam.
Artist and graphics designer Patience Phillips (Halle Berry) is a meek people pleaser whose only support is her best friend Sally (Alex Borstein). She works for a cosmetics company called Hedare Beauty, which is ready to ship a new skin cream called Beau-Line, that is able to reverse the effects of aging. However, as Patience visits the factory where it is being manufactured, she overhears a discussion between the scientist, Dr. Ivan Slavicky (Peter Wingfield), and Laurel Hedare (Sharon Stone), the wife of company owner George Hedare (Lambert Wilson); speaking about the dangerous side effects from continued use of the product. Laurel's guards discover Patience and are ordered to dispose of her. Patience tries to escape using a conduit pipe, but the minions have it sealed and flush her out of it, drowning her. Lying washed up on the shore and lifeless, Patience is mysteriously brought back to life by an Egyptian Mau cat, who appeared at her apartment earlier, and from that moment on develops cat-like abilities.
Gus Gorman, a chronically unemployed loser, discovers he has a talent for computer programming and gets a job at the Metropolis-based conglomerate Webscoe. Gus, dissatisfied with his pay, embezzles from his employer using a technique known as salami slicing, which brings Gus to the attention of CEO Ross Webster. Webster is intrigued by the computer's potential to aid him in his schemes to rule the world financially. Joined by his sister Vera and his "psychic nutritionist," Lorelei Ambrosia, Webster blackmails Gus into helping him.