Nero Wolfe is a fictional character, an armchair detective created in 1934 by American mystery writer Rex Stout. Wolfe's confidential assistant Archie Goodwin narrates the cases of the detective genius. Stout wrote 33 novels and 39 short stories from 1934 to 1975, with most of them set in New York City. Wolfe's residence features prominently in the series, a luxurious brownstone on West 35th Street. Many radio, television, and film adaptations have been made from the stories.

The Nero Wolfe corpus was nominated for Best Mystery Series of the Century at Bouchercon 2000, the world's largest mystery convention, and Rex Stout was a nominee for Best Mystery Writer of the Century.