This is the parallel story of a love story and a war. Dupati Hari Babu (Varun Tej) is a lower caste man studying in Chennai, in 1936. He falls in love with a girl named Sita (Pragya Jaiswal) who studies with him. They end up falling in love with each other. And after finishing their college, they go back to their hometown, a village named Devarakonda. There, Hari's grandfather and mother live in the same house. Eventually, Hari adjusts with the style of the village, realizing he is from a lower caste. But that does not matter to Hari or Seeta, and they are still in love, though nobody knows about it. Hari makes friends with Eeshwar (Nikitin Dheer), Seeta's brother who is very close with her. Eeshwar eventually finds out about the love birds, and tells his grandfather who raised them about Hari and Seeta's love story. His grandfather then raises a fight between castes in the village, and believes that when all the castes are fighting, it will kill Hari as well. The fights get very serious, and hundreds of people start dying from both the sides. This causes the villagers to set up 2 fences for each caste side, and no one from either of the castes is supposed to cross the fence of the latter. While all this happens, Eeshwar and his grandfather find a nice groom for Seeta and try to marry her off to that man.
Krishnam Vande Jagadgurum starts with Devika (Nayantara) documenting illegal mining in Bellary by Reddappa (Milind Gunaji), a ruthless business tycoon. Reddappa burns down a village so that the people leave, because under it is a large iron ore deposit, which he wants to mine. The villagers, especially Matti Raju (L.B. Sriram), want to kill Reddappa to take revenge. It is later revealed that Devika is not a journalist but an informer of the CBI.
Abhiram Abhi (Sharwanand) is the son of a multi-millionaire GK. He is born and brought up in comfort and luxury; for him life is just a game and he is accustomed to a lavish lifestyle. He is portrayed to be a happy-go-lucky character and quite popular with the women. He comes across Janaki (Kamalinee Mukherjee), a young, charming doctor. Abhi tells his friends that he will make her fall in love in few days. Abhi invites Janaki for coffee after a dance programme and proposes to her.