Après son évasion de prison, Shredder s'allie avec le savant fou Baxter Stockman et deux hommes bêtes et costauds, Bebop et Rocksteady. Grâce à un puissant mutagène violet, ces deux derniers sont transformés en monstres ressemblant à un phacochère et un rhinocéros. De leur côté, les Tortues sont toujours aidées par April O'Neil, Vern Fenwick et un nouveau venu, le justicier hockeyeur masqué Casey Jones, pour contrecarrer ses plans. Cependant, ils doivent très vite faire face à une menace encore plus grande : Krang.
In the summer of 1982, Sam Brenner and Will Cooper are thirteen-year-olds who love playing in the local arcade. Brenner enters an arcade game world championships. At the event, the MC tells that a time capsule will be launched into space containing a videocassette that includes scenes from the championships. Brenner and Cooper meet Ludlow Lamonsoff, a child who's in love with Lady Lisa, the main character of the game Dojo Quest. Brenner succeeds in every game, but finally loses to Eddie Plant in Donkey Kong.
On November 12, 1955, Marty McFly discovers that his friend, Dr. Emmett "Doc" Brown, had become trapped in 1885. Marty, with the 1955 Doc, uses the information in Doc's 1885 letter to locate and repair the DeLorean. He spots a tombstone with Doc's name, dated six days after the letter. Learning that Doc was killed by Biff Tannen's great-grandfather, Buford "Mad Dog" Tannen, Marty travels back to 1885 to save Doc.
Flint Lockwood is a wannabe-scientist who lives in Swallow Falls, a tiny island in the middle of the Atlantic Ocean that has sardines as the base of its economy. Flint lives with Tim, his widowed technophobic father who misunderstands his son's talent, and his pet monkey, Steve. Despite Flint's zealous enthusiasm, his inventions, including spray-on shoes, a remote controlled television, rat birds, hair-un-balder, and a flying car, all ended in failure.
Michael Newman (Adam Sandler) is a hardworking architect who is married to his longtime sweetheart, Donna (Kate Beckinsale) with two children, Ben and Samantha. Michael is easily pushed around by his overbearing boss, Mr. Ammer (David Hasselhoff). On numerous occasions, Michael willingly sacrifices time with his family to work so he can give them the kinds of possessions he never had. While going in search of a universal remote control at the retail store Bed Bath & Beyond, Michael falls onto a bed and then proceeds to the section marked "Beyond". There, he befriends a mysterious man named Morty (Christopher Walken), who gives him a "universal" remote control and warns that it can never be returned.
Eccentric scientist and inventor Wayne Szalinski lives in his suburban home attempting to perfect a ray gun capable of shrinking objects, but the apples he uses as test objects instead blow up. After an argument between Wayne and his wife Diane, she spent the night with her mother and is currently at work, worrying her teenaged daughter Amy, and their son Nick, who has inherited his father's inventive ingenuity and intelligence. Next door neighbors; the Thompsons, are getting ready for a fishing trip, but Russ' oldest son Little Russ is less than enthusiastic, as he and his father's interests often clash, resulting in his feeling belittled, and he is more interested in meeting Amy than spending the weekend camping. Younger son Ron, however, is enthusiastic, though his relationship with Russ Sr. is strained when he inadvertently sets off a booby trap in the yard.
Starting in a small section of the near South, both U.S. Army Captain James West and U.S. Marshal Artemus Gordon hunt for Confederate General "Bloodbath" McGrath, who is wanted for mass murder. It points back to when McGrath ordered a massacre in a settlement called New Liberty, where many of the freed slaves were murdered, including West's biological parents. The search leads to a brothel where the two try (unsuccessfully) to arrest him. It leads to a huge brawl and a cart of nytroglycerin crashing into the building that starts a fire. Both West and Gordon, the latter dressed as a woman, escape.
Katie (Jenny McCarthy) and Becky (Pamela Anderson) are talking about a tape, which Katie thinks is a sex tape, but Becky refers to a cursed tape (The Ring). After several odd occurrences, they die. In a farm outside Washington, D.C., widowed farmer and former reverend Tom Logan (Charlie Sheen) and his clumsy younger brother George (Simon Rex) discover a crop circle, saying "Attack Here!" (Signs).
Five years after saving New York City from the demi-god Gozer, the Ghostbusters—Egon Spengler, Ray Stantz, Peter Venkman, and Winston Zeddemore—have gone their separate ways after having been sued by the city for property damage and barred from investigating the supernatural, forcing them out of business. Ray owns an occult bookstore and works as an unpopular children's entertainer with Winston, Egon works in a laboratory on the Columbia University campus, conducting experiments into human emotion, and Peter hosts a pseudo-psychic television show. Peter's former girlfriend Dana Barrett has had a son, Oscar, with a violinist that she married then divorced when he received an offer to join the London Symphony Orchestra. In order to take care of her baby, Dana quit her former cellist profession and now works as a restorer at the fictional Manhattan Museum of Art, working to prepare a malevolent-looking portrait of a legendary sixteenth-century tyrant named Vigo the Carpathian of Moldavia for an upcoming exhibition.
As a crime wave rises in New York City, Channel 3 news reporter April O'Neil talks about rumors of young children and teenagers being reported as the majority of the thieves, connecting it to a rumored Foot Clan, which originated in Japan. On an ordinary night, she comes across thieves stealing from a news van and is attacked. She is rescued and one of her rescuers leaves behind a sai as police arrive to collect the beaten criminals. In the storm sewers, four anthropomorphic turtles return to their underground home and meet with their master Splinter, who advises them to remain hidden from the world and work only in the shadow. Raphael admits he lost his weapon, and when the others order pizza he leaves in disguise to see a movie. After leaving the movie, he encounters Casey Jones who tries to exact justice on a pair of muggers by beating them with sporting implements. After a brief stand off between the two, Casey takes off into the city and Raphael loses his temper. Returning home, Splinter confronts Raph about his temper.
Shaquille O'Neal and Dr. Phil awaken to find themselves chained to pipes in a spoof of Saw. Their host, Billy the Puppet, reveals the room is filling with nerve gas. The only way to get the saws was to make a basket. Shaq misses twice, injuring Phil, but still managed to get the saws. Phil realizes they have to cut through their own feet. Shaq tricks Phil into doing so, but accidentally saws off the wrong foot, inadvertently leaving both men to die.
Professor Philip Brainard (Robin Williams) of Medfield College is developing a new energy source, in an attempt to raise enough money to save the college from closure. His preoccupation with his research distracts him from his fiancée, the college president Sara Jean Reynolds (Marcia Gay Harden). He has missed two weddings because of that preoccupation, much to Sara's anger. On the day of the third attempted wedding, Philip is approached by his former partner Wilson Croft (Christopher McDonald), who has profited from ideas he has stolen from the chemist and now desires to steal Sara from Philip and make her his wife, which he declares directly to Philip. Before he can make it to the wedding, his latest experiment shows fast development, forcing him to miss another wedding. The resulting substance created from the experiment is a green goo that increases in speed as it bounces and proves to be difficult to control, wreaking havoc on the neighborhood before the professor finally manages to capture it. Weebo (voiced by Jodi Benson), Philip's hovering robot assistant, classifies the substance as "flying rubber", leading Philip to christen it as "Flubber".
John Brown is a humble, but clumsy security guard working at the Bradford robotics laboratory in Riverton, Ohio, run by Artemus Bradford and his daughter Brenda, whom Brown has a crush on. Brown wishes to become a police officer, with support from his niece Penny. Brenda and Artemus create a lifelike robotic foot as part of the Gadget Program, to create cybernetically augmented police officers. Tycoon Sanford Scolex attacks the lab, steals the foot, and has Artemus murdered before escaping in his limo. Brown goes chasing him down in his car, which leads to its being destroyed by Scolex's explosive cigar leaving brown for dead, but a bowling ball coming from the fiery blast of Brown’s destroyed car smashingly crushes Scolex's hand, forcing him to replace it with a mechanical claw.
In 2286, a large cylindrical probe moves through space, sending out an indecipherable signal and disabling the power of ships it passes. As it takes up orbit around Earth, its signal disables the global power grid and generates planetary storms, creating catastrophic, sun-blocking cloud cover. Starfleet Command sends out a planetary distress call and warns starships not to approach Earth.