In the Yukon Territory in 1931, Albert Johnson (Charles Bronson), a solitary American trapper, comes across an organized dog fight. A white German Shepherd is badly injured and Johnson forcibly takes it, paying $200 to its owner, a vicious trapper named Hazel (Ed Lauter).
A vamp commuter takes refuge with her neighbor, half a bag lady rather ugly and suicidal. Believing murderess of her alcoholic husband policeman and she just put it out of harm's way, she embarks on his escape her neighbor and an offender on the run almost despite himself.
The movie begins with Eugene (Zach Cregger) and his best friend Tucker (Trevor Moore) as kids. They sneak into the bedroom closet of Eugene's brother, as he recently acquired a valuable Michael Jordan rookie card. Upon opening the box the card was in, Tucker notices that Eugene's brother has an issue of Playboy. Tucker opens the magazine, instantly becoming obsessed with it. Three weeks later, Tucker's demeanor has changed to that of a hormone driven teenager, despite that he is only 8 years old. Fast forward ten years later, Eugene and Tucker are seniors in high school.
Spoiled heiress Ellen "Ellie" Andrews has eloped with pilot and fortune-hunter "King" Westley against the wishes of her extremely wealthy father, Alexander, who wants to have the marriage annulled as he is aware that Westley is only really interested in her money. Jumping ship in Florida, she runs away, boarding a bus to New York City, to reunite with her new spouse, when she meets fellow bus passenger Peter Warne, a freshly out-of-work newspaper reporter. Soon Warne recognizes her and gives her a choice: If she will give him an exclusive on her story, he will help her reunite with Westley. If not, he will tell her father where she is. Ellie agrees to the first choice. As they go through several adventures together, Ellie loses her initial disdain for him and begins to fall in love. When they have to hitchhike, Peter fails to draw attention until Ellie displays a shapely leg to Danker, the next driver. When they stop en route, Danker tries to steal their luggage; but Peter seizes his car. Nearing the end of their journey, Ellie confesses her love to Peter. When the owners of the motel in which they are staying notice that Peter's car is gone, they expel Ellie. Believing Peter has deserted her, Ellie telephones her father, who agrees to let her marry Westley. Meanwhile, Peter has obtained money from his editor to marry Ellie, but misses her on the road. Although Ellie has no desire to be with Westley, she believes Peter has betrayed her for the reward money, and agrees to have a second, formal wedding to Westley. On her wedding day, she finally reveals the whole story. When Peter comes to Ellie's home, Mr. Andrews offers him the reward money, but Peter insists on being paid only his expenses: a paltry $39.60. When Ellie's father presses him for an explanation of his odd behavior, Peter admits he loves Ellie, and storms out. Westley arrives for his wedding via Kellett K-3 Autogyro NC12691; but at the wedding ceremony, Mr. Andrews reveals Peter's refusal of the reward money to Ellie, sends her to Peter, and pays Westley off.
Behind the opening credits, the film opens on a suburban Los Angeles street with teenager Jim Stark (Dean) drunkenly lying down on a sidewalk. He is arrested and taken to the juvenile division of the police station for "plain drunkenness". At the station he meets John "Plato" Crawford (Mineo), who was brought in for shooting a litter of puppies with his mother's gun, and Judy (Wood), who was brought in for curfew violation (she was wearing a bright red dress with matching lipstick and was mistaken for being a streetwalker). The three each separately reveal their innermost frustrations to officers; all three of them suffer from problems at home:
Michael Bannon (Michael Sarrazin), a wealthy but bored businessman and candymaker, issues the code word "Gumball" to his fellow automobile enthusiasts, who gather in a garage in New York City to embark on a coast-to-coast race "with no catalytic converter and no 55-mile-per-hour speed limit," in the shortest amount of time and only one rule: "There are no rules." Their nemesis, LAPD Lieutenant Roscoe (Normann Burton), also learns of the race and most of the film is devoted to the adventures of the various driving teams and Roscoe's ineffectual attempts to apprehend them. A number of running gags ensue – the Jaguar that will not start; the silent Lapchik's (Harvey Jason) numerous mishaps; Italian race driver Franco Bertollini's (Raúl Juliá) frequent detours to seduce beautiful women – as well as some stunts and driving sequences. The race ends at the Queen Mary in Long Beach, California where the finishers celebrate their adventures and the defeated Roscoe sulks off to one side – until a fleet of police cars and tow trucks, summoned by Roscoe, arrive to impound the Gumball vehicles. Roscoe had contrived to see to it that all of them were guaranteed to be illegally parked once the post-race party in the parking lot ran past 11 PM. Bannon congratulates Roscoe on his final victory (final because Roscoe, who has been after Bannon and Smith since they were in high school, has reached mandatory retirement) and again utters the command "Gumball" to initiate a race back to New York.
As three sailors – Gabey, Chip, and Ozzie – begin their shore leave, Gabey falls in love with the picture of "Miss Turnstiles", who is actually Ivy Smith. The sailors race around New York attempting to find her in the brief period they have ("New York, New York").
Itinerant western singer Red Stovall (Clint Eastwood), suffers from tuberculosis but has been given an opportunity to make it big at the Grand Ole Opry. He is accompanied by his young nephew Whit (Kyle Eastwood), to Nashville, Tennessee.
In 1995, Samantha Darko (Chase) follows her best friend Corey (Evigan) on a road trip from Virginia to California, in an attempt to become professional dancers. Their dreams are cut short when their car breaks down in a tiny Utah town. They are saved by the town bad boy, Randy (Westwick), who takes them to the local motel where they meet the conspiracy-loving owner. He tells them of Billy Moorcroft, a boy who went missing.
The story opens with the children's grandfather, D.J. Mulrooney (Walter Brennan), a well-known executive officer of a vast timber-trading company. D.J. is an eccentric and passionate man with a distinctive snore, as well as vast dedication and determination. D.J. is going to Seattle to sell 50,000 acres of timberland. D.J. takes his personal, customized 1930 Rolls-Royce Phantom II on the trip. In a brief conversation with his Company Head of Security, Ralph Yarby (Richard Deacon), we learn that the car was purchased after D.J. earned his first US$1 million. His first stop is The Airport where he picks up his grandchildren Elizabeth (Karen Dotrice) and Rodney (Matthew Garber) who are to accompany D.J. on his trip to Seattle. The children ask about the Rolls, to them an unusual car, and D.J. compares the Rolls with his first car back in Ireland, a one horsepower "Jaunty Car".
The story revolves around the odd relationship between two vagabonds: Max Millan (Gene Hackman), a short-tempered ex-convict, and Francis Lionel "Lion" Delbuchi (Al Pacino), a childlike ex-sailor. They meet on the road in California and agree to become partners in a business, once they reach Pittsburgh.
George Cox, Victor Vialat and Eddie Carpentier are old and shabby broke actors. They will resume unexpectedly with panache but three small roles in a light comedy, bound for a tour. Shapiron, producer, ruined, will do anything to sabotage the show and thus get the insurance but the three actors will not let the last chance of life.
Bright lights descend from the night sky, tracing routes over four desert highways, eventually converging on an isolated crossroads. Lightning flashes and blue smoke are the result of their high-speed collision, revealing a sleek, all black Dodge M4S Turbo Interceptor, driven by a black-clad and helmeted figure.
One night, Caleb Colton (Adrian Pasdar), a young man in a small town, meets an attractive young drifter named Mae (Jenny Wright). Just before sunrise, she bites him on the neck then runs off. The rising sun causes Caleb's flesh to begin to burn. Mae comes with a group of roaming vampires and takes him away. The most unsociable of all the vampires, the callous and sociopathic Severen (Bill Paxton), wants to kill Caleb, but Mae reveals she has turned him into a vampire. Their charismatic leader, Jesse Hooker (Lance Henriksen), reluctantly agrees to allow Caleb to remain with them for a week to see if he can learn to hunt and become a trusted member of their group. Caleb is unwilling to kill to feed, which alienates him from the others. To protect him, Mae kills for him and then has him drink from her wrist. After Caleb endangers himself to help them during a daylight police raid on their motel, Jesse and the others are temporarily mollified.
Arizona deputy sheriff Walt Coogan is sent to New York City to extradite escaped killer James Ringerman. Detective Lieutenant McElroy informs him that Ringerman is recovering from an overdose of LSD, cannot be moved until the doctors release him, and that Coogan needs to get extradition papers from the New York State Supreme Court.