In June 1950, while stationed at Kimpo, South Korea, Captain George Slocum (John Hodiak) finds out from his friend, Lieutenant Jerry Barker (Todd Karns), that he has to go to Japan. At the airport, he meets Barker's younger brother, Pete (John Derek), who takes up a Stinson L-5 Sentinel liaison aircraft and begins showing off. George reprimands him for careless flying, but sticks up for him when the military police want to arrest Pete.
During the Korean War, while American Air Force pilots Lt. John Willard (William Bryant) and his brother Frank (Dick Paxton) are flying a routine reconnaissance mission, their commanding officer, Col. Ed Wyatt (Dan Duryea) orders them to bomb an enemy position. Frank's aircraft is shot down, and John returns to confront his commander over the reason for the dangerous mission. Wyatt's executive officer, Maj. Scott (Michael Fox) stops him and relates a story about Wyatt's career during World War II.
Four employees on an oil company crash-land in the desert and face a slow death, until they discover a German Panzer from World War II buried in the sand.
A US Navy Lockheed TV-2 jet piloted by Captain Dale Heath (Efrem Zimbalist Jr.), with an enlisted man (Troy Donahue) as a passenger, runs into trouble as soon as it is in the air. Both Heath's radio and his navigation system become disabled, with no way to correctly determine their altitude. At the same time, a Douglas DC-7 airliner piloted by veteran Dick Barnett (Dana Andrews), is carrying a full load of passengers, each with their own worries and problems to deal with.
Chicago air traffic controller Jack Harris (Kiefer Sutherland) was cleared of liability for an ill-fated flight under his authority, such that resulted in the loss of all 174 souls aboard. He subsequently left the job and went on to design air control software, until five years later when T.C. Bryant (Bruce McGill), his ex-colleague who had since transferred to Phoenix, pleads for help on New Year's Eve due to a critical staff shortage and with torrential weather predicted. His return to the control room is met with warmth and disdain, particularly when he experiences flashbacks of the historic incident. The atmosphere rapidly becomes much more serious as the storm approaches and with the control tower suffering power cuts, the team is forced into manually directing busy air traffic through severe turbulence.
When a deranged criminal is caught, he is then being transported on a Boeing 747-100 to New York, along with some other criminals. Through a stroke of luck he is able to subdue the Federal agents assigned to bring him, free the other criminals, and take over the 747. He then threatens to crash the 747 into a populated area unless his demands are met. The FBI agent who captured him then decides to get on the 747 while in flight to do something. He does but things don't go as planned, and the criminal continues his plan to crash the 747 unless the agent can do something, the military is going to shoot the plane down.
The film opens in Los Angeles International Airport where fans and haters of heavy metal singer Slade Craven (John Mann) gather up. Craven will perform his farewell concert on a Boeing 747 operated TransCon Airlines flight 619, which will be flying from Los Angeles to Toronto, and the concert is scheduled to be broadcast over the internet. The FAA has received threats that they had better allow this concert to take place. Erica Black (Monika Schnarre) is a news anchor who is on the airplane with her cameraman Ethan (Ben Derrick), covering the concert. The fans board the plane and later Craven and his band get on while the crew checks everything. During the safety demonstration, the fans do not pay attention and they cheer saying Craven many times. There are several shots of people cheering, and also some close-ups as well. The faces of the stewardesses are shown and it is clear that they are frustrated. The fans are shown as well, and some have makeup on, and rock -n- roll hair styles.
Lieutenant Robert Banks (Buddy Rogers), a young American aviator in the Lafayette Escadrille, on leave in Paris, meets Mary Gordon (Jean Arthur), a young American living abroad. Their romance is cut short by his return to the front. In an air battle, Robert brings down and captures von Baden, nicknamed the "Grey Eagle" (Paul Lukas), and takes him to Allied headquarters in Paris, to obtain intelligence on German plans.
A Uruguayan rugby team crashes in the Andes Mountains and has to survive the extremely cold temperatures and rough climate. As some of the people die, the survivors are forced to make a terrible decision between starvation and cannibalism.
Test pilot Joe Kovak (Stanley Clements) work for Sam Bentley (John Litel), the former partner of Joe's deceased father. Because Joe's father was killed while flying, however, his mother (Dorothy Adams) is afraid for her son. Bentley is competing for an important government contact but Joe is putting the effort into jeopardy as his brash attitude and propensity in disobeying orders, is becoming troublesome.
The young pilot Toby Jugg (Pattinson) is cut down with his plane during a bombing on the city of Dresden during World War II. This incident forced him on the wheelchair and his aunt Julia (Stirling), decides to take him to a nursing home in Wales, headed by Dr. Hal Burns (Sands), in hopes that he will manage to recover.
In 1942 an Australian fighter pilot is shot down behind enemy lines in Singapore. In evading the enemy through the jungle, he encounters an anti-Japanese Chinese guerrilla from Dalforce who is also separated from his comrades in arms. Despite being unable to speak each other's language, the two work together to make their way to safety.