The Genesect Army comes to a mountainous, snowy area that used to be their home. However, three hundred million years have passed, and it is no longer habitable. Suddenly, an avalanche occurs, but Mewtwo arrives and manages to save four of the five Genesect. Mewtwo peers into the mind of the Douse Drive Genesect and learns what they are looking for: their home. The Red Genesect, whom Mewtwo was unable to save, then appears and attacks Mewtwo, and the Genesect Army flies off. Later, they see the skyline of a large city and mistake it for their home, leading them to travel there.
Dr. Lawrence Angelo works for Virtual Space Industries, running experiments in increasing the intelligence of chimpanzees using drugs and virtual reality. One of the chimps escapes using the warfare tactics he was being trained for. Dr. Angelo is generally a pacifist, who would rather explore the intelligence-enhancing potential of his research without applying it for military purposes.
Business tycoon and billionaire Damian Hale (Ben Kingsley) is master of his own universe, until he is diagnosed with terminal cancer. Now on his deathbed, he finds a business card directing him to a man named Professor Albright (Matthew Goode), who informs him about a radical medical procedure called "shedding", in which one's consciousness is transferred to an artificially grown healthy body. Damian decides to undergo the procedure and engineers his own public death. Albright transfers him into a new body (Ryan Reynolds) and prescribes medication to alleviate vivid hallucinations which he claims are side effects of the procedure.
When Josh Ockmann (Jonathan Tucker) enters a dark university library intending to meet his friend Douglas Zeigler (Kel O'Neill), he is attacked by a humanoid spirit that sucks the life force out of him. Some days later, Josh's girlfriend, Mattie Webber (Kristen Bell), visits his apartment, seeing evidence that it has not been well kept. Josh tells Mattie to wait in the kitchen while he walks off. While waiting she finds Josh's pet cat, locked in a closet dying from severe malnutrition. But when she rushes to tell him, she finds he has committed suicide by hanging himself with an Ethernet cable.
Teresa "Terry" Doolittle (Whoopi Goldberg) transfers funds for the First National Bank in Manhattan, New York. She does not quite fit with the bank's corporate image, despite being a good employee and popular with her co-workers. She is often chastised by her no-nonsense boss James Page (Peter Michael Goetz).
Alex Rogan is a teenager living in a trailer park with his mother and little brother, Louis. Alex often plays Starfighter, an arcade game in which the player defends "the Frontier" from "Xur and the Ko-Dan Armada" in a space battle. He becomes the game's highest-scoring player, and is approached by the game's inventor, Centauri, who invites him to take a ride. Alex does so, discovering the car is a spacecraft. Centauri is an alien who takes him to the planet Rylos. An android duplicate named Beta takes Alex's place during his absence.
The film focuses on Celebi, who travels to the future with a boy named Sam while being chased by a hunter. Meanwhile, Ash, Misty, Brock, and Pikachu are on their way to the next gym in their Johto journey and get a lift from a man named Maki, who takes them to his hometown of Arborville. They see a Suicune (who was actually the first Pokémon Ash saw in Johto). When they plan to enter a forest that is claimed to have many unusual and rare Pokémon, they are warned by an elderly lady about the "Voice of the Forest", which may carry a person off to a different period in time unless those hearing it stand still.
The film opens with a character in a video game entering an eerie mansion. He is followed throughout the mansion by a woman in a red dress, who kills him by hanging him from a chandelier. The man playing the game is Loomis Crowley (Milo Ventimiglia), and the game is called Stay Alive. Loomis later wakes up to find his roommate and his roommate's girlfriend slaughtered. He is then hanged from a chandelier and killed, similar to the way he died in the game.
Genetic engineers Clive Nicoli (Adrien Brody) and Elsa Kast (Sarah Polley) hope to achieve fame by splicing animal DNA to create hybrids for medical use at the company N.E.R.D. (short for Nucleic Exchange Research and Development). Their work previously yielded Fred, a dog-sized vermiform creature intended as a mate for their female specimen, Ginger. After successfully mating them, Clive and Elsa plan to create a human-animal hybrid that could revolutionize science. Their employers Joan Chorot (Simona Maicanescu) of N.E.R.D. and William Barlow (David Hewlett) forbid them from doing this. Instead, they are to find and extract proteins used for commercial drug production from Fred and Ginger. Clive and Elsa pursue their own agenda in secret. They develop a viable female creature (Abigail Chu).
The film opens with Jack “Jackie” Walker, a Pokémon ranger undercover, infiltrating Phantom the Pirate’s ship and retrieving a special Pokémon egg to prevent Phantom’s selfish desires. Jackie manages to escape with the help of a Mantine, a water/flying type Pokémon. Sometime later Ash Ketchum along with his Pikachu, Brock, May, and her younger brother Max stumble upon the Marina Group, a traveling family circus consisted of water and psychic-type Pokémon. They meet Elizabeth, the star and daughter of Kyle and Meredith, performers and Kyle’s father Chip, the conductor. They kindly take in Ash and the others who are suffering from dehydration in the wasteland. After a performance at a nearby town, May discovers the same egg shown earlier in the film by the Marina Group’s pet Buizel, a water-type Pokémon. A clown apparently traveling with the group takes away the egg and hands it to Elizabeth. That night, May has a dream with her encountering a temple under the sea and a mysterious Pokémon. That morning she explains it to everyone and it turns out that Marina Group have all had that dream and tell the others about a group of people called the People of the Water, stating that they are in relation with them. Meanwhile, Team Rocket; Jessie, James and Meowth raid the Marina Group’s trailer for the egg and attempt to hand it over to Phantom. They fail when the Marina Group’s clown reveals himself as Jack Walker who captures a Fearow to retrieve it.
In a country called "Diamond Domain" (ダイヤモンド鉱国, Daiyamondo Kōkoku) lies the powerful Heart Diamond (聖なるダイヤ, Seinaru Daiya, "Holy Diamond"), which has served as the kingdom's source of energy and maintained the Ore Country for centuries. Many Carbink live in Diamond Domain, including their princess - the Jewel Pokémon, Diancie, who created the Heart Diamond. Diancie no longer has the power to control the Heart Diamond and her country is falling into chaos as a result.
Set in San Francisco, California, down-on-his-luck Naval aviator Lt. Tuck Pendleton (Quaid) resigns his commission and volunteers for a secret miniaturization experiment. He is placed in a submersible pod and both are shrunk to microscopic size. They are transferred into a syringe to be injected into a rabbit, but the lab is attacked by a rival organization, led by scientist Dr. Margaret Canker (Fiona Lewis), that plans to seize the experiment and steal the miniaturization technology.
Ingrid Thorburn est une jeune femme fragile psychologiquement et accro à Instagram, fascinée par la vie de rêve de ses influenceuses préférées. Un jour, blessée profondément parce qu'elle n'a pas été invitée au mariage de rêve d'une « amie » Instagram, elle sabote la fête et se retrouve à l'hôpital psychiatrique. Lorsqu'elle en sort, de retour sur son iPhone après ce dérapage, elle jette son dévolu sur Taylor Sloane, une autre instagrameuse influente et célèbre qui vit en Californie. Ingrid, avec l'argent de l'héritage de sa mère récemment morte, quitte la Pennsylvanie et se rend à Los Angeles, bien décidée à devenir la meilleure amie de Taylor...
In Los Angeles, Lt. Parker Barnes and John Donovan are tracking down a serial killer named SID 6.7 at a restaurant in virtual reality. SID (short for Sadistic, Intelligent, Dangerous - a VR amalgam of the most violent serial killers throughout history) puts Donovan into shock, killing him. The director overseeing the project, before Commissioner Elizabeth Deane and her associate, William Wallace, order the programmer in charge of creating SID, Dr. Darrel Lindenmeyer, to shut down the project. Barnes is a former police officer imprisoned for killing political terrorist Matthew Grimes, who killed Parker's wife and daughter and innocent bystanders. This caused Barnes to become a convicted killer and serve 17 years to life.
Sacha et son Pikachu arrive à Fula où se tient l'annuel Festival du Vent. Cette célébration honore le Pokémon légendaire Lugia qui avait fait don de ses vents à la ville après avoir vu les liens qui unissaient les Pokémon et leurs dresseurs. Mais les festivités tournent au cauchemar: les vents s'arrêtent soudainement de souffler et la Team Rocket diffuse accidentellement un nuage toxique sur la ville. Sacha doit alors s'allier de compagnons insolites afin de sauver les habitants: un menteur compulsif, la fille du maire, une vielle dame refusant tout contact avec les Pokémon, un scientifique timide et une athlète en manque de confiance. Alors que tous coopèrent pour sauver le festival, un Pokémon mystérieux, Zeraora, tâche de sauver les Pokémon de la forêt.