In a world populated by anthropomorphic vehicles, the last race of the Piston Cup championship ends in a three-way tie between retiring veteran Strip "The King" Weathers, infamous runner-up Chick Hicks, and rookie Lightning McQueen. The tiebreaker race is scheduled for one week later at the (fictional) Los Angeles International Speedway in California. Lightning is desperate to win the race, since it would allow him to leave the unglamorous sponsorship of Rust-Eze, a rust treatment for old cars, and allow him to take The King's place as the sponsored car of the lucrative Dinoco team. Eager to start practice in California as soon as possible, he pushes his big rig, Mack, to travel all night long. While McQueen is sleeping, the exhausted Mack drifts off and is startled by a gang of four reckless street racers, causing McQueen to fall out the back of the trailer and into the road. McQueen wakes in the middle of traffic and speeds off the highway to find Mack, only to end up in the run-down desert town of Radiator Springs, and inadvertently ruining the pavement of its main road.
Several years after the events of the series, Jim Phelps (Jon Voight) and his team, the Impossible Mission Force, are assigned to retrieve the IMF non-official cover list from the American embassy in Prague. Their mission fails: Phelps is shot point blank, his wife Claire (Emmanuelle Beart) dies in a car bombing, and the rest of the team except agent Ethan Hunt (Tom Cruise) are eliminated by an unknown assassin. Meeting later with IMF director Eugene Kittridge (Henry Czerny), Hunt learns the job was a setup designed to lure out a mole within IMF, whom IMF believes to be in contact with an arms dealer known as "Max" as part of "Job 314." As Hunt is the only member left, Kittridge suspects him of being the mole, and Hunt flees.
Following his pursuit by Kirill, Jason Bourne (Matt Damon) evades Moscow police. Six weeks later, CIA Deputy Director Pamela Landy (Joan Allen) divulges the audiotaped confession of Ward Abbott, the late former head of Operation Treadstone, to Director Ezra Kramer (Scott Glenn). Meanwhile, in Turin, journalist Simon Ross (Paddy Considine) of The Guardian meets an informant to learn about Jason and Operation Blackbriar, the program succeeding Treadstone. The CIA tracks Ross as he returns to London, after his mention of "Blackbriar" during a cell-phone call to his editor is detected by the ECHELON system. Jason reappears in Paris to inform Martin Kreutz (Daniel Brühl), the step-brother of his girlfriend Marie Helena Kreutz (Franka Potente) of her assassination in India.
In 2029, Human Resistance leader John Connor (Jason Clarke) launches a massive final offensive against Skynet, an artificial general intelligence system seeking to eliminate the human race. Before the Resistance wins the offensive, Skynet activates a time machine and sends back a T-800 Terminator to 1984 to kill John's mother, Sarah Connor (Emilia Clarke). John's right-hand man, Kyle Reese (Jai Courtney), volunteers to travel back in time to protect her. As Kyle floats in the machine's magnetic field, he witnesses John being attacked by another Resistance soldier (Matt Smith). He then has visions from his childhood about events in 2017.
John Connor has been living off the grid in Los Angeles in the years following the death of his mother, Sarah, from leukemia. Although Judgment Day did not occur on August 29, 1997, as expected, John still believes that a war between humans and the machines will occur. Unable to locate John in the past, Skynet sends a new model of the Terminator called the T-X back to July 24, 2004 to kill other members of the Human Resistance. The T-X is more advanced than previous Terminators, and has an endoskeleton with built-in weaponry, a liquid metal exterior similar to the T-1000, and the ability to reprogram other machines. Unlike previous Terminators, its standard appearance is female. The Resistance sends a reprogrammed Terminator (T-850 - Model 101) back in time to protect the T-X's targets including John and his future wife, Kate Brewster.
In 1989, Kevin Flynn, software engineer and the CEO of ENCOM International, disappears. Twenty years later, his son Sam, now ENCOM's primary shareholder, takes little interest in the company beyond playing an annual prank on its board of directors.
A saber-toothed squirrel (known as Scrat) is trying to find a place to store his prized acorn. Eventually, as he tries to stomp it into the ground, he causes a large crack in the ground that extends for miles and miles and sets off a large avalanche. He barely escapes, but finds himself stepped on by a herd of prehistoric animals. The animals are trying to avoid the ice age by migrating south. Sid, a clumsy ground sloth left behind by his family, decides to move on by himself but is attacked by two Brontops whom he angered. Sid is soon saved by Manfred ("Manny"), an agitated mammoth who fights them off and is heading north. Not wanting to be alone and unprotected, Sid follows Manny. Meanwhile, Soto, the leader of a Smilodon pride, wants revenge on a group of humans by eating the chief's baby son, Roshan, alive. Soto leads a raid on the human camp, during which Roshan's mother is separated from the rest and jumps down a waterfall when cornered by Soto's lieutenant, Diego. For his failure, Diego is sent to find and retrieve the baby.
Harry Tasker leads a double life, performing covert missions for the U.S government under a counter-terrorism task force called "The Omega Sector" using the cover of a traveling computer salesman. Albert "Gib" Gibson and Faisal assist him in these missions under the command of Spencer Trilby. However, Harry's wife, Helen, and his daughter, Dana, believe he is a boring computer salesman who does a lot of "corporate" travel. Harry's latest mission in Switzerland reveals the existence of a Persian terrorism organization group known as the Crimson Jihad, led by Salim Abu Aziz. Harry suspects that antiques dealer Juno Skinner has ties to Aziz. After visiting her, Harry is chased by Aziz's men through a shopping mall and a large hotel, meanwhile missing the birthday party that his wife and daughter have arranged for him.
Following a nuclear holocaust, the world has become a desert wasteland and civilization has collapsed. Max Rockatansky, a survivor, is captured by the War Boys, the army of the tyrannical Immortan Joe, and taken to Joe's Citadel. Designated a universal blood donor, Max is imprisoned and used as a "blood bag" for a sick War Boy called Nux. Meanwhile, Imperator Furiosa, one of Joe's lieutenants, is sent in her armored truck, the "War Rig", to collect gasoline. When she drives off-route, Joe realizes that his five wives—women selected for breeding—are missing. Joe leads his entire army in pursuit of Furiosa, calling on the aid of nearby Gas Town and the Bullet Farm.
At the funeral of his son Marko and associates in Tropojë, Albanian mafia head Murad Hoxha vows to seek vengeance on his son's killer. Traveling to Paris with his men, he interrogates and tortures former intelligence agent Jean-Claude Pitrel, whose business card was found at the scene of Marko's death, but finds no information. He then bribes a corrupt police official for Pitrel's files and deduces that his old friend Bryan Mills was responsible and is in Istanbul.
In 2003, Dr. Serena Kogan (Helena Bonham Carter) of Cyberdyne Systems convinces death row inmate Marcus Wright (Sam Worthington) to sign over his body for medical research following his execution. One year later, the automated Skynet system is activated, begins to perceive humans as a threat, and eradicates much of humanity with nuclear weapons in the event known as "Judgment Day".
Five years after leaving Los Angeles, Dominic Toretto and his new crew, consisting of his girlfriend Letty, Tego Leo, Rico Santos, Cara Mirtha, and Han Seoul-Oh, are hijacking fuel tankers in the Dominican Republic. Dominic begins to suspect that the police are hot on their trail, after Han informs him that one of his garages have been raided, forcing the crew to disband and go their separate ways. Realizing that he must move, he packs his things in the middle of the night and leaves Letty behind in order to protect her from harm.
Two years after the events in Bangkok, Leslie Chow (Ken Jeong) escapes from a maximum security prison, using a riot as cover. Meanwhile in America, Alan Garner (Zach Galifianakis) causes a 20-car freeway pileup after he purchases a giraffe and accidentally decapitates it on a low overpass. Alan's father Sid (Jeffrey Tambor), angry with Alan for his immature antics and never owning up to his mistakes, dies of a heart attack in the middle of a lecture. After the funeral, Alan's brother-in-law Doug Billings (Justin Bartha) informs friends Phil Wenneck (Bradley Cooper) and Stu Price (Ed Helms) that Alan has been off his ADHD medication and is out of control. They attend an intervention, in which Alan agrees to visit a rehab facility in Arizona, so long as "the Wolfpack" takes him there. On the way to Arizona, Phil's minivan is rammed off the road by a rental truck and the group is taken hostage. They are later confronted by mob boss Marshall (John Goodman) and "Black Doug" (Mike Epps), his head enforcer.
In the aftermath of the death of Dracula's wife Martha (Jackie Sandler) at the hands of an angry mob, Count Dracula (Adam Sandler) designs and builds a massive five-star hotel in Transylvania in which to raise his daughter Mavis (Selena Gomez) and to serve as a getaway for all the world's monsters.