Dix ans après, Tallahassee, Columbus, Wichita et Little Rock font toujours équipe et luttent ensemble pour survivre face aux zombies, qui avec le temps ont évolué : parmi les zombies simples sont apparus les « Homer », en surpoids et simples d'esprit, les « Hawking », capables de stratégie, les « ninjas », rapides et silencieux, mais surtout les « T-800 », plus féroces et résistants aux balles. Le groupe trouve un temps refuge dans la Maison-Blanche. Mais des tensions apparaissent dans le groupe : Columbus et Wichita vivent leur petite vie de couple jusqu'à ce que Columbus demande la main de Wichita, et Tallahassee « couve » Little Rock comme un père, alors que cette dernière, devenue jeune adulte, a des envies d'ailleurs et d'être avec des gens de son âge. Une nuit, Wichita et Little Rock décident de partir à bord de la voiture blindée et surarmée de Tallahassee.
In an unspecified Victorian-era village somewhere in Europe, Victor Van Dort (Johnny Depp), the son of nouveau riche fish merchants, and Victoria Everglot (Emily Watson), the neglected daughter of hateful aristocrats, are preparing for their arranged marriage, which will raise the social class of Victor's parents and restore the wealth of Victoria's penniless family. Both have concerns about marrying someone they do not know, but upon meeting for the first time, they fall for each other. After the shy Victor ruins the wedding rehearsal and is scolded by Pastor Galswells (Christopher Lee), he flees and practices his wedding vows in the nearby forest, placing the wedding ring on a nearby upturned tree root.
About eight years after a zombie apocalypse, R, a zombie, spends his days wandering around an airport which is now filled with hordes of his fellow undead, including his best friend M. R and M achieve rudimentary communication with grunts and moans and occasional near-words. As a zombie, R constantly craves human flesh, especially brains, as he is able to "feel alive" through the victims' memories he experiences when he eats them.
Avec sa femme Rachel et leurs deux jeunes enfants Ellie et Gage, le docteur Louis Creed quitte Boston pour s'installer dans une région rurale du Maine. Au fond des bois près de sa nouvelle maison, Ellie découvre un vieux cimetière pour animaux de compagnie dans lequel des générations d'habitants de la région ont enterré leurs animaux de compagnie préférés. Peu après, une tragédie s’abat sur la famille : Church, le chat d'Ellie, meurt écrasé par un camion. Louis se tourne alors vers un étrange voisin, Jud Crandall. Celui-ci l'emmène au-delà du cimetière pour animaux, jusqu'à un cimetière indien. Il lui propose alors d'enterrer Church dans cette zone peu hospitalière. Sans le savoir, Jud et Louis viennent de déclencher une série d’événements tragiques avec de redoutables forces maléfiques. Pour sa part, Rachel est obnubilée par des visions de sa sœur, jadis morte dans de tristes circonstances, et dont le souvenir vient sans cesse la hanter.
In the small town of Blithe Hollow, Massachusetts, Norman Babcock (Kodi Smit-McPhee) is an 11-year-old boy who speaks with the dead, including his late grandmother (Elaine Stritch) and various ghosts in town. Almost no one believes him and he is isolated emotionally from his family while being ridiculed by his peers. His friend, Neil Downe (Tucker Albrizzi), is an overweight boy who is bullied himself and finds in Norman a kindred spirit. During rehearsal of a school play commemorating the town's execution of a witch three centuries ago, Norman has a vision of the town's past in which he is pursued through the woods by townsfolk on a witch hunt. Afterward, the boys are confronted by his estranged and seemingly deranged uncle Mr. Prenderghast (John Goodman) who tells his nephew that he soon must take up his regular ritual to protect the town. Soon after this encounter, Prenderghast dies from a sudden stroke. During the official performance of the school play Norman has another vision, creating a public spectacle of himself which leads to his father (Jeff Garlin) grounding him. His mother (Leslie Mann) tells him that his father's stern manner is because he is afraid for him. The next day, Norman sees Prenderghast's spirit who tells him that the ritual must be performed with a certain book before sundown that day. Norman is at first reluctant to go because he is scared but his grandmother tells him it is all right to be scared as long as he does not let it change who he is. Norman sets off to retrieve the book from Prenderghast's house (having to take it from his corpse).
Underneath Raccoon City exists a genetic research facility called the Hive, owned by the Umbrella Corporation. A thief steals the genetically engineered T-virus and contaminates the Hive with it. In response, the facility's artificial intelligence, the Red Queen, seals the Hive and kills everyone inside.
Two months have passed since a mutated strain of mad cow disease mutated into "mad person disease" that became "mad zombie disease" which overran the entire United States population, turning American people into vicious zombies. Unaffected college student "Columbus" (Jesse Eisenberg) is making his way from his college dorm in Austin, Texas to Columbus, Ohio to see whether his parents are still alive. He encounters "Tallahassee" (Woody Harrelson), another survivor who is particularly violent in killing zombies. Though he does not appear to be sociable, Tallahassee reluctantly allows Columbus to travel with him. Tallahassee mentions he misses his "puppy" that was killed by zombies, as well as his affinity for Twinkies, which he actively tries to find. Survivors of the zombie epidemic have learned that it is best not to grow attached to other survivors, because they could die at any moment, so many have taken to using their city of origin as nicknames, i.e. "Columbus" is from Columbus, Ohio.
After finishing a long shift, nurse Ana returns to her suburban neighborhood and her husband, Luis. Caught up in a scheduled date night, they miss an emergency news bulletin. The next morning, a neighborhood girl enters their bedroom and kills Luis, who immediately reanimates as a zombie and attacks Ana. She flees in her car but crashes and passes out. Upon waking, Ana joins with Police Sergeant Kenneth Hall, electronics salesman Michael, petty criminal Andre and his pregnant wife, Luda. They break into a nearby mall and are attacked by a zombified security guard, who scratches Luda. They are also confronted by three living guards — C.J., Bart, and Terry — who make them surrender their weapons in exchange for refuge. They split into groups to secure the mall and then go to the roof, where they see another survivor, Andy, who is stranded alone in his gun store across the zombie-infested parking lot.
An injured, terrorized girl is being chased down in the woods. The men who capture her take her to some cabin's basement. They believe she is possessed by an evil entity so they have her tied to a column. Her own father is among them, and as she tries to convince him that there's nothing wrong with her, she slowly loses control and eventually it becomes clear that she is in fact possessed. In response to this her father pours flammable liquid on her, sets her on fire, then shoots her in the head.
Un chauffeur de camion est arrêté sur une petite route par des hommes portant des tenues de protection contre les risques biologiques. Ils désinfectent son véhicule avant de le laisser passer. Peu après, il percute une chevrette qui, bien que morte, se relève.
In Cambridge, three animal liberation activists break into a medical research laboratory with the intent of freeing captive chimpanzees. They are interrupted by a scientist, who desperately warns them that the chimps are infected with a highly contagious rage-inducing virus that is spread through blood and saliva. Ignoring the scientist's pleas, the activists release a chimpanzee, who attacks one of them and immediately infects her — leading her to attack and infect everyone else present.
In the underground Facility, senior technicians Gary Sitterson and Steve Hadley discuss plans for a mysterious ritual. A similar operation undertaken by their counterparts in Stockholm has just ended in failure.
The Archangel Michael (Paul Bettany) falls to Earth in Los Angeles and cuts off his wings. He steals a police car after a policeman is killed by another officer who is possessed. He travels towards the Paradise Falls Diner, near the edge of the Mojave Desert. Meanwhile, Kyle (Tyrese Gibson), a single father driving to Los Angeles, stops at the diner. He meets the owner, Bob Hanson (Dennis Quaid); Bob's son, Jeep (Lucas Black); Percy (Charles S. Dutton), the short-order cook; Charlie (Adrianne Palicki), a pregnant waitress; Howard (Jon Tenney) and Sandra (Kate Walsh) Anderson, a married couple; and Audrey (Willa Holland), their rebellious teenage daughter. An old woman (Jeanette Miller) enters the diner and begins taunting the diner's patrons. When Howard confronts her, she rips his throat open, screeches that they are all going to die, and climbs up the ceiling. Kyle shoots her before she can kill Jeep. Percy, Kyle, Sandra, Audrey and Charlie try to get Howard to the hospital but they are forced to turn back after passing through a swarm of flies.
During the original outbreak of the Rage Virus, Don, his wife Alice, and four other survivors hide in a barricaded cottage on the outskirts of London. They hear a terrified boy pounding at their door, and let him in. A few minutes later, they discover that the infected have followed the boy to them. The infected attack and kill most of the survivors, while Don, Alice, and the boy are chased upstairs. Don is separated from Alice and when the boy is seen hiding in the closet. Alice rushes to get the boy, while Don tells her to just leave him. Soon the infected break into the room and after Alice pleading with Don to "help us", he decides to leave, abandoning them. Don desperately sprints to a nearby motorboat and narrowly escapes.
At the start of the film, the US Government has ordered a branch of the US Military to discontinue tests concerning "the C.H.U.D. project", which is built around the idea that enzymes taken from the sewer dwelling creatures from C.H.U.D. can make hyper-effective killing machines in the army. For reasons that are unclear even to those who watch the film, the last specimen of the experiment (BUD the C.H.U.D.) is hidden away in a Centre for Disease Control in a small American town, where a trio of bumbling teenagers steal and accidentally reawaken him. Bud escapes and begins to forge an army of C.