In the present-day American Midwest, society struggles to function in the aftermath of a zombie pandemic barely under control. Maggie Vogel (Abigail Breslin) calls her father from a broken city under curfew; her voicemail urges that he not seek her and that she loves him. Her arm was bitten. Knowing she has only weeks before the "necroambulist virus" turns her cannibalistic, she left home to protect her family. Maggie's father Wade (Arnold Schwarzenegger) has searched two weeks, despite her warning. Finding her in a hospital for the infected, he brings Maggie home to care for her until she must eventually be quarantined. During their return, a zombie attacks Wade at an abandoned gasoline station and he breaks its neck.
A young female traveler, Charlotte (Émilie Dequenne) gets into a fight with a group of bikers. After this, she meets Max, a hitchhiker. The two stop off at La Spack, a rundown roadside eatery run by a woman (Yolande Moreau), after whom the restaurant is named. The biker gang reappears and is chased off by the owner of the restaurant. Moments later, Max vanishes after heading to the bathroom. Charlotte elects to investigate at nightfall to the spot where Max disappeared. Charlotte later finds herself bound and caged, a prisoner of La Spack, who sees her as the next meal for her brood, a pack of ghouls.
In the mining town of Gold Lick, Oregon, Jeff (Taylor Sharpe), a young fan of B movie actor Bruce Campbell, and his friend Clayton (Logan Martin) go out to a cemetery to meet two girls, Big Debbie (Ariel Badenhop) and Little Debbie (Ali Akay). Jeff removes a medallion off the mausoleum, unleashing the Chinese god of the dead, Guan-Di (James Peck), who kills Clayton and the Debbies while Jeff flees.
The prologue follows the actions of National Guard Sergeant "Nicotine" Crockett, who along with Kenny, Francisco and Tomboy, desert their posts and rob the protagonists of the previous film.
A group of friends gather to attend a wedding on a remote island in Istanbul. During the event, zombies appear and attack the guests. All of the events and the group's attempts to survive the zombie invasion are recorded on a camcorder by one of the friends.
While working in the church, Grace finds a hidden crypt. While exploring she discovers a voodoo book, however she is soon sent away by Father Cornelius. Grace's son, Nathan attends the local high school, with his friends Henry and Diggs. Nathan likes his long-time friend Jessica however is too scared to ask her out, in case he is rejected. Also in the school are popular girls Charlotte, Glenda and Cheryl. Cheryl pursues Nathan, despite already having a boyfriend, Samson, who confronts Nathan along with his womanising friend Kenneth after seeing Cheryl talking to Nathan. Meanwhile, Henry and Diggs, fed up with Nathan not asking out Jessica, force the pair to meet after school.
The film opens on a sleepy gas station, where the slack-jawed pump attendant (Charles Baker) is attacked by a seemingly rabid animal. Through a series of glimpses the attendant's body begins to contort after the attack. Meanwhile, a young couple, Seth Belzer (Paulo Costanzo) and Polly Watt (Jill Wagner), retreat to the wilderness for a romantic camping trip in the ancient forests of Oklahoma, but their plans are shattered when they are car-jacked by an escaped convict, Dennis Farell (Shea Whigham), and his drug-addict girlfriend, Lacey Belisle (Rachel Kerbs). As the foursome travel the back roads together, they get a flat tire when they run over a small splinter infected animal on the road. Finding shelter at the now abandoned gas station, they fend off larger incarnations of a parasite as it infects more victims.
In Louisiana's Seven Doors Hotel in 1927, a lynch mob murders an artist named Schweick, whom they believe to be a warlock. This opens one of the Seven Doors of Death, allowing the dead to cross into the world of the living. Several decades later, Liza, a young woman from New York, inherits the hotel and plans to re-open it. Her renovation work activates the hell portal, and she contends with increasingly strange incidents. A plumber named Joe investigates flooding in the cellar and a demonic hand gouges out his eye. His body and another are later discovered by a hotel maid, Martha.
In a building site being developed by Hartman Construction in the East End of London, two construction workers discover a 17th-century graveyard ordered sealed by Charles II. When they enter to search for treasure they are bitten by zombies, setting off a zombie outbreak in the area.
After his girlfriend Beth Slocum (Aubrey Plaza) dies, Zach Orfman (Dane DeHaan) is left devastated. He begins to spend time with Beth's parents Maury (John C. Reilly) and Geenie (Molly Shannon) as a source of comfort. Zach confesses to Maury that he and Beth were having problems in their relationship; Maury advises him not to let the end of the relationship define it.
The story opens in a small French village 10 years after World War II. The villagers refer to a small nearby lake known as the "lake of the damned." A group of young women go skinnydipping in the lake and are attacked by zombie Nazi soldiers who drown them. The zombies later leave the lake and attack women within the town. The mayor of the town (Howard Vernon) refuses to take action against the zombie attacks until reporter Katya Moore (Marcia Sharif) arrives to investigate.
In the town of Dillford, Vampires, Humans and Zombies used to get along, but with the arrival of extraterrestrial beings, it's humans vs. vampires vs. zombies in all-out mortal combat. Now three teenagers must try to get things back to "normal."
The film opens with a man, later revealed to be named BJ, in a morgue who has sex with a corpse that has a biohazard symbol on the toe tag; afterward, he handles an empty test tube while washing up. Later, at a party, Samantha unsuccessfully attempts to contact her ex-girlfriend Nikki and meets with her friend Alice, who encourages Samantha to drink to forget about her recent break-up. Riley, who has an unrequited crush on Samantha, and Zain attempt to flirt with her, but Samantha brushes them off and excuses herself. She eventually gives in to Alice's intense pressure and becomes drunk. BJ introduces himself to Samantha and hands her a drink that he claims she dropped. Samantha, too drunk to know whether it is her drink or not, accepts it. Although she says she is a lesbian who is already involved in a relationship, as a result from being drunk and drugged, she agrees to have intercourse with BJ. From inside his car, Samantha begs BJ to stop and eventually blacks out.
Après qu'une épidémie se soit répandue dans toute l’Australie et qu'il ait perdu sa femme suite à la morsure d’un zombie, un père (Martin Freeman) cherche une bonne personne prête à garder sa fille Rosie.