Child psychologist Catherine Deane (Jennifer Lopez) is an expert in an experimental treatment for coma patients: a virtual reality device that allows her to enter into the minds of her patients and attempt to coax them into consciousness. When serial killer Carl Rudolph Stargher (Vincent D'Onofrio) falls into a coma before the FBI can locate his final victim, Agent Peter Novak (Vince Vaughn) persuades Deane to enter Stargher's mind and discover the victim's location. Stargher's victim is imprisoned in a cell in the form of a glass enclosure that is slowly filling with water by means of an automatic timer.
Adam, a young photographer, awakens in a filthy bathtub. He gets out and finds himself chained to by one foot to a pipe in a large dilapidated bathroom. Lawrence Gordon, an oncologist, is chained by one foot to a pipe across the room and between them lies a corpse, holding a revolver and a microcassette recorder. Adam manages to retrieve the recorder and they learn from tapes in their pockets what they must do: Adam must escape the bathroom, and Lawrence must kill Adam before six o'clock, or his wife and daughter will die and he will be left to die as well. Using a clue from the tape, Adam finds a bag in the toilet tank containing two hacksaws, though neither is able to cut through their chains. Adam's saw breaks and he throws it at a mirror in frustration. Lawrence realizes the saws are meant to be used on their feet and identifies their captor as the Jigsaw Killer, whom Lawrence knows of because he was once a suspect.
On the Valentine's Day of 1997, in a small town, a cave-in on the north side of a Hanninger mine trapped six miners. Six days later, rescue teams found five dead miners and the comatose Harry Warden (Richard John Walters), who survived by killing the other miners with a pickaxe, allowing himself to breathe. Tom Hanniger (Jensen Ackles), the mine owner's son, was blamed for the mine disaster because he forgot to vent the methane lines and caused a cave-in, but also Harry Warden for killing the miners.
An injured, terrorized girl is being chased down in the woods. The men who capture her take her to some cabin's basement. They believe she is possessed by an evil entity so they have her tied to a column. Her own father is among them, and as she tries to convince him that there's nothing wrong with her, she slowly loses control and eventually it becomes clear that she is in fact possessed. In response to this her father pours flammable liquid on her, sets her on fire, then shoots her in the head.
On the 15th anniversary of the Woodsboro Massacre, high school students Jenny Randall and Marnie Cooper are attacked and brutally murdered in their home by a new Ghostface.
In 1973, 14-year-old Susie Salmon dreams about becoming a photographer. One day, Ray, a boy she has a crush on, approaches her at school and asks her out. As Susie walks home through a cornfield, she runs into her neighbor, George Harvey, who coaxes her into his underground den. Inside, Susie becomes uncomfortable and attempts to leave; when he grabs her, the scene fades until she is seen rushing past classmate Ruth Connors, apparently fleeing Harvey's den.
On June 13, 1980, a young Jason Voorhees (Caleb Guss) watches as his mother Pamela (Nana Visitor) is beheaded by a camp counselor (Stephanie Rhodes), who was trying to escape Mrs. Voorhees's murder spree around Camp Crystal Lake. Almost 30 years later, a group of vacationing friends—Wade (Jonathan Sadowski), Richie (Ben Feldman), Mike (Nick Mennell), Whitney (Amanda Righetti) and Amanda (America Olivo)—arrive at Crystal Lake on a camping trip to search for marijuana growing in the woods. That night, Jason (Derek Mears), now an adult, begins to kill members of the group, but spares Whitney and abducts her because she resembles Pamela at a young age.
One year after the explosion of Flight 180, college student Kimberly Corman is headed to Daytona Beach, Florida for spring break with her friends, Shaina McKlank, Dano Estevez, and Frankie Whitman. En route, Kimberly has a premonition of wooden logs falling off a semi, causing a massive car crash that kills everyone involved. She stalls her car on the entrance ramp, preventing lottery winner Evan Lewis; widow Nora Carpenter and her fifteen-year-old son Tim; businesswoman Kat Jennings; stoner Rory Peters; pregnant Isabella Hudson; high school teacher Eugene Dix; and Deputy Marshal Thomas Burke from entering the highway. While Thomas questions Kimberly, the pileup occurs. Shaina, Dano, and Frankie are killed by a speeding truck, but Kimberly is saved by Thomas at the last second.
A convict introduced as "Malcolm Rivers"—who was abandoned as a child at a motel by his prostitute mother—awaits execution for several vicious murders that took place at an apartment building. Malcolm's psychiatrist, Dr. Mallick, has discovered his journal that may explain why he committed the murders. With this late evidence brought forth, a new hearing takes place.
On July 4, 1969, an unknown male attacks Darlene Ferrin and Mike Mageau with a handgun, at a lovers' lane in Vallejo, California. Mageau survives; Ferrin dies.
The film begins in medias res with a recorded 911 call of a boy screaming that he and his friend found two bodies lying in blood in an old vacation house.
In 1941, an eight-year-old Hannibal Lecter lives in Lecter Castle in Lithuania. Hitler's invasion of the Soviet Union turns the Baltic region into part of the bloodiest front line of World War II. Lecter, his younger sister Mischa, and their parents travel to the family's hunting lodge in the woods to elude the advancing German troops. After three years, the Nazis are finally driven out of the countries soon to be occupied by the Soviet Union. During their retreat, however, they destroy a Soviet tank that had stopped at the Lecter family's lodge looking for water. The explosion kills everyone but Lecter and Mischa. They survive in the cottage until six former Lithuanian militiamen, led by a Nazi collaborator named Vladis Grutas, storm and loot it. Finding no other food in the bitterly cold Baltic winter, the men look menacingly at Lecter and Mischa.
Police Constable Nicholas Angel, a high-achieving member of the Metropolitan Police Service, is promoted to Sergeant but it comes with being transferred to the village of Sandford, Gloucestershire, for being too good at his job while making his colleagues look bad by comparison due to his skills. Angel finds the town is generally devoid of any crime, with its local Neighbourhood Watch Alliance (NWA) helping to keep the peace as everyone prepares for the "Village of the Year" award contest. Angel finds minor instances of disorderly conduct, during which he confiscates a shed full of unlicensed fire arms including a naval mine, pursues an escaped swan, and arrests a drunk driver who turns out to be his new partner PC Danny Butterman, the son of town chief Inspector, Frank Butterman.
On Halloween in Haddonfield, Illinois, having already shown signs of psychopathic tendencies, 10-year-old Michael Myers (Daeg Faerch) murders a school bully. Later that night, he murders his older sister Judith (Hanna R. Hall), his mother’s abusive boyfriend Ronnie (William Forsythe), and Judith's boyfriend Steve (Adam Weisman). Only his baby sister, Angel Myers, is spared. After one of the longest trials in the state’s history, Michael is found guilty of first degree murder and sent to Smith's Grove — Warren County Sanitarium under the care of child psychologist Dr. Samuel Loomis (Malcolm McDowell).
Police psychologists review recordings of a man (Robert De Niro), who states his name as Detective David Fisk, the "Poetry Boy" killer. The Poetry Boy earned the moniker for his modus operandi of murdering criminals and leaving short poems with their bodies. Fisk reveals that he looks up to his partner of almost 30 years, Tom Cowan (who the audience is led to believe is the character portrayed by Al Pacino), and considers him to be his role model of how a cop should be. Pacino's character is known by the nickname "Rooster" and De Niro's by "Turk," and they are referred as such outside of the recordings.